U.S. Environmental Protection Agency, National Center for Environmental Assessment (MS117), 26 West Martin Luther King Drive, Cincinnati, OH 45268

A -- RISK ASSESSMENT RESEARCH IN DISEASE TRANSMISSION MODELING FOR PATHOGENS IN DRINKING WATER SOL NCEA-CIN-06 DUE 101698 POC Barbara Cook, FAX No. (513) 569-7475 E-MAIL: Click here to e-mail EPA Contact, cook.barbara@epamail.epa.gov. Invitation To Submit Preproposals for Cooperative Agreements RISK ASSESSMENT RESEARCH IN DISEASE TRANSMISSION MODELING FOR PATHOGENS IN DRINKING WATER The United States Environmental Protection Agency, National Center for Environmental Assessment -- Cincinnati Office (NCEA-CIN), seeks research proposals for development of a disease transmission model for human disease occurrence following exposure to pathogens in drinking water in both endemic and epidemic situations. Areas of interest include: 1) developing a general quantitative, population-based, dynamic disease transmission model for pathogens found in drinking water and, 2) application of the quantitative, dynamic disease transmission models for selected pathogens found in drinking water, such as Cryptosporidium sp., Giardia sp., enteroviruses and bacteria such as E. coli 0157:H7 These mathematical models must include variables that represent the dynamic interplay that can exist between pathogen, host, and environmental factors such as: phenotypic and genotypic characteristics that influence virulence, pathogenicity, and host specificity; environmental occurrences, variable source water quality, water treatment plant performance and extreme-events; population susceptibility/immunity including sensitive populations (due to age, immune status, medications, genetic predisposition, pregnancy and nutritional status), dose-response, the spectrum of disease including asymptomatic and symptomatic infections, duration of illness, mortality and sequelae. The intent is to develop one or more three year cooperative agreements on the announced research areas of interest with the primary purpose of supporting or stimulating research on risk assessment of pathogens in drinking water. EPA scientists will collaborate in the research by providing risk assessment data, exposure information, expertise in microbiology and statistics, and by participating in authorship of research publications/presentations. Preproposals must not exceed seven (7) pages and will be thoroughly reviewed and evaluated by a technical evaluation panel of scientists. Successful Preproposals will be invited to submit a competitive cooperative agreement application including a full and detailed project proposal for funding consideration. Depending on funding availability, the awards are estimated to range from $100,000 to $300,000 over 3 years. Interested applicants must be eligible to receive Federal Assistance under the Clean Water Act (CWA), Section 104(b)3, the Safe Drinking Water Act (SDWA), Section 1442. ONLY STATE AND LOCAL GOVERNMENTS, NONPROFIT RESEARCH INSTITUTIONS OF HIGHER EDUCATION, INDIVIDUALS, OR NONPROFIT RESEARCH ORGANIZATIONS ELIGIBLE TO RECEIVE FEDERAL ASSISTANCE UNDER THESE ACTS SHOULD SUBMIT A REQUEST FOR A PREPROPOSAL. Preproposals from other Federal Agencies are not solicited and will not be accepted. Interested parties may obtain a copy of Solicitation for Pre-Applications #NCEA-CIN-06 by contacting Barbara Cook, USEPA, National Center for Environmental Assessment -- Cincinnati Office, MS-117, 26 W. ML King Dr., Cincinnati, Ohio 45268, FAX: 513-569-7475, E-mail:cook.barbara@epamail.epa.gov. Request for Solicitation package must be postmarked no later than October 16, 1998. ORAL REQUESTS WILL NOT BE ACCEPTED. Posted 09/18/98 (W-SN251894). (0261)

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