National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

A -- PREVENTION OF CARDIOVASCULAR DISEASE IN DIABETES MELLITUS -- COORDINATING CENTER SOL NHLBI-HC-99-17 DUE 033199 POC Mr. John Taylor, Contracting Officer, 301-435-0350 The National Heart, Lung, and Blood Institute is soliciting proposals for a Coordinating Center to participate in a multi-center clinical trial to study the prevention of cardiovascular disease in diabetes mellitus. The period of performance is for nine-years beginning on or about September 30, 1999 through September 30, 2008. The study will consist of a Coordinating Center, approximately 8 Clinical Network Centers, a Pharmacy Distribution Center, and the following subcontracted laboratories under the Coordinating Center: a Core ECG Laboratory, a Core Chemistry Laboratory, and a Core Retinal Photography Laboratory. A planned total of 10,000 patients will be randomized into six intervention or control groups in a 3-by-2 factorial design. The Coordinating Center will have the responsibility for the overall coordination, monitoring, and central management of all activities of the study, including communications, study protocol, manual of operations, data collection and quality control, and data analysis and reporting. This is an unrestricted competition and this announcement invites all responsible sources interested in performing as the Coordinating Center for this study (RFP No. NHLBI-HC-99-17) to submit a proposal which shall be considered by the agency. This is not a Request For Proposal (RFP); the RFP will be available on or about December 28, 1998, and must be downloaded from the NIH Web Site at the following Internet address: http://www.nhlbi.nih.gov/nhlbi/rafs/rfas.htm. The due date for proposals will be March 31, 1999. Posted 12/10/98 (W-SN279299). (0344)

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