A&MMS (573/90C), Veterans Administration Medical Center, 1601 Archer Road, Gainesville, Florida 32608-1197

B -- CLINICAL VA MERIT REVIEW STUDY SOL RFP 573-012-99 DUE 123198 POC Marilyn Gray, Contract Specialist, phone 352/374-6007 or FAX# 352/379-7437 This notice is not intended to solicit proposals, but for informational purposes only. The VA Medical Center in Gainesville, Florida intends to negotiate a sole source contract with the University of Florida, Department of Medicine beginning 1/1/99 for one year with four optional years for renewal. The overall objective of this study entitled, Angiotensin IV receptor regulation of lung endothelium no synthase with the Prinicipal Investigator being J. M. Patel, PhD are: (1) characterize the angiotensin IV (Ang-IV)-specific binding sites in lung endothelial cells; (2) examine the mechanisms by which Ang-IV binding results in increased catalytic activity of endothelial cell nitric oxide synthase (ecNOS) protein; and (3) establish the causal relationship between Ang-IV binding and activation of ecNOS and NO/cyclic guanosine monophosphate (cGMP) signaling and verify in vivo vasodilator response of Ang-IV using organ bath model. Authority 6.302. See Note 22. Posted 12/10/98 (W-SN279293). (0344)

Loren Data Corp. http://www.ld.com (SYN# 0015 19981214\B-0001.SOL)