National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- STUDIES TO EVALUATE THE TOXIOCOLOGIC AND CARCINOGENIC POTENTIAL OF SELECTED CHEMICALS IN LABORATORY ANIMALS BY ORAL AND DERMAL EXPOSURE -- DIISOPROPYLCARBODIMIDE, METHYLENE BLUE, BROMOCHLOROACETIC ACID, DIBROMOACETONITRITE, DICHLOROACETIC ACID, AND BROMODICHLOROACETIC ACID. SOL NIH-ES-99-28 DUE 030999 POC Marilyn B. Whaley, Contract Specialist, 919-541-0416; Allan C. Benton, Contracting Officer, 919-541-467- WEB: NONE, NONE. E-MAIL: NONE, NONE. The NIEHS is soliciting offers for a contract to evaluate the toxicologic and carcinogenic potential of selected chemicals of interest via oral or dermal administration. This project includes 2-year studies of methylene blue and diisopropylcarbodiimide; 14-day, 90-day, and 2-year studies of dibromoacetonitrile, bromochloroacetic acid, and bromodichloroacetic acid, and 90-day and 2-year studies of dichloroacetic acid. Multiple studies shall be conducted concurrently. The base contract shall consist of Phase 1 for all six chemicals to include those work activities associated with the determination of bulk chemical purity and identity, and validation of dose formulation/analysis methods, and any health and safety concerns. Upon successful completion of Phase 1, the Government may unilaterally exercise options for the conduct of 14-day, 21-day, 90-day, or 2-year studies specified as Phases 2 through 4. These studies shall be conducted according to the Specifications for the Conduct of Studies to Evaluate the Toxic and Carcinogenic Potential of Chemical, Biological and Physical Agents in Laboratory Animals for the National Toxicology Program dated August, 1992, with subsequent revisions. Offerors shall have a working laboratory involved in conducting studies by the required routes of administration in place by the date of proposal submission. The Principal Investigator, Toxicologist, Chemist, Health and Safety Officer and Quality Assurance Unit Officer shall be employees of the contract laboratory (i.e., not consultants or subcontractors). The daily interaction and constant coordination of efforts needed amongst these discipline areas throughout the in-life portion of the studies makes it critical that they be physically and organizationally together. Award of one cost-reimbursement, completion type contract on September 30, 1999 on an open competition basis is contemplated as a result of this solicitation. The estimated level of effort is 2,360 labor hours for the base contract and 165,325 labor hours for all options. The estimated period of performance is approximately eight months for the base contract and four years five months if all options are exercised. Interested organizations should request either a streamlined or full RFP package. If no selection is made, a streamlined version of the RFP will be provided, which will include only the Statement of Work, deliverables and reporting requirements, special requirements, mandatory qualifications, and technical evaluation criteria. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP by written, telephonic ((919) 541-0416), or telefax request ((919) 541-2712). The electronic version of the CBD synopsis and the RFP (which will be available on or about January 8, 1999 without the NTP specifications) is available on the Internet at: http://www.niehs.nih.gov/dert/rcb/rfp.htm. All responsible sources may submit a proposal which shall be considered by the Agency. Expected release date of the RFP is January 8, 1999 with proposals due March 9, 1999. Posted 12/21/98 (W-SN282193). (0355)

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