National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- RODENT PRODUCTION CENTER SOL NIH-ES-99-27 DUE 031599 POC Contact Velvet M. Torain, Contract Specialist, 919/541-0400/Phillip D. Jones, Contracting Officer, 919/541-0426 WEB: NONE, NONE. E-MAIL: NONE, NONE. The objectives of this project are to establish, operate, and maintain rodent production colonies under strict barrier conditions to product 50 to 350 animals of each sex of F344 rats and B6C3F1 hybrid mice and other strains per week for a total of approximately 40,000 rodents per year. The Government may require production of other species/strains of rodents as needed without increasing the total number of animals produced. The rats and mice to be produced shall share identical microflora; therefore, both species may be produced in the same barrier unit. However, to facilitate production of peaks, two barriers production units/rooms may be used. Each barrier production unit shall have both species but one unit shall be stocked to produce peaks of rats and the second for peaks of mice. Having two production units for the standard species/strains will provide back up in the event of contamination or ventilation systems failure of one unit. The Contractor shall maintain several isolators and two or more maximum barrier units or rooms dedicated to this contract. The Contractor shall have the capability to rederive not only the standard strains F344, C57BL/6N (e84) and C3H/HeN (e84), but also special strains such as (but not limited to) transgenic rodents by embryo transfer or Cesarean section and establish defined (modified Schaedler) microflora-associate foundation colonies. The contractor shall establish production colonies of rats by random mating and bybrid mice by mating C57Bl/6N (e84) females with C3H/Hen (e84) males to produce 50 of each sex of F344 rats and 150 of each sex of B6C3F1 hybrid mice per week with peaks up to 350 animals of each sex and species at four to eight week intervals as requested by the Government. The estimated period of performance is eight (8) years. The Government estimates that this eight year period may require approximately 121,520 labor hours. This acquisition is a total small business set aside, the size standard for which is 500 employees. See Numbered Notes 1 and 26.***** Posted 12/30/98 (W-SN284130). (0364)

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