National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Solar Bldg., Room 3C07, 6003 Executive Blvd. MSC 7610, Bethesda, MD 20892-7610

A -- STEM CELL TRANSPLANTATION FOR THE TREATMENT OF AUTOIMMUNE DISEASES SOL NIH-NIAID-DAIT-BAA-99-31 DUE 033199 POC Mrs. Cyndie W. Cotter, Contracting Officer, 301-402-0641 The Division of Allergy, Immunology and Transplantation (DAIT) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), has a requirement for Contractors to conduct clinical research on stem cell transplantation for the treatment of multiple autoimmune diseases. The overall purposes of this BROAD AGENCY ANNOUNCEMENT (BAA) are to solicit proposals for: (1) the design, performance, and analysis of clinical trials to evaluate the safety, toxicity and efficacy of stem cell transplantation for the treatment of multiple autoimmune diseases; (2) integrated studies of the underlying mechanisms of this therapeutic approach, including the identification and assessment of immunologic and other relevant parameters responsible for and/or associated with response to therapy, short- and long-term clinical outcome, and recurrence/remission of the underlying autoimmune disease; and, (3) an optional component focused on the establishment of core resources/repositories useful for further basic and clinical research on stem cell transplantation. RFP NIH-NIAID-DAIT-BAA-99-31 will be available electronically on or about February 1, 1999, and may be accessed through the NIAID Contract Management Branch (CMB) Homepage by using the following electronic address and instructions: NIAID-CMB Homepage (via the World Wide Web): access by: http://www.niaid.nih.gov/contract and select the "RFPs" link. Please note that the RFP for this acquisition has been revised to include only the Research and Technical Objectives, deliverable and reporting requirements, special requirements, and mandatory qualifications, if any, the Technical Evaluation Criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and review, offerors may be requested to provide additional documentation to the Contracting Officer. Proposals in response to this RFP will be due on or about March 31, 1999. Any responsible offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. It is anticipated that two cost-reimbursement contracts will be awarded for a maximum period of five (5) years. Point of Contact: Cyndie Cotter, Contracting Officer Electronic Mail Address: cc41w@nih.gov Telephone: (301) 402-0641 Telefax: (301) 402-0972 No collect calls will be accepted. Posted 01/13/99 (W-SN287814). (0013)

Loren Data Corp. http://www.ld.com (SYN# 0004 19990115\A-0004.SOL)