National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- QUALITY ASSESSMENT FOR GENOMIC SEQUENCE SOL NIH-HG-99-30 POC Velvet M. Torain, Contract Specialist, 919/541-0400/Phillip D. Jones, Contracting Officer, 919/541-0426, Fax No. 919/541-2712 WEB: NONE, NONE. E-MAIL: NONE, NONE. The objectives of this project are to assess the quality of the genomic sequence produced by Government funded sequencing centers. Initially quality assessment shall generally follow the protocols used in previous quality assessment exercises. The potential Contractor shall reassemble the data electronically and perform restriction analysis to check the data producer's assemble. The assembly will be compared to the sequencing center's consensus sequence in GenBank, and all discrepancies identified. The potential Contractor shall be able to use whatever base calling and data assembly programs are used by the sequencing centers, moreover, the software used by the Contractor shall be compatible with that used by the Sequencing Centers so that all results will be accurate, reliable, and comparable between sequencing centers and the Contractor. A detailed quality assessment report shall be provided to the Project Officer. The potential contractor shall include an outreach capability to provide advice to theSequencing Centers with their in-house quality control programs. The Contractor shall be expected to attend and participate in meetings of the Research Network Committee held in Bethesda, Maryland. The Contractor shall also provide logistical support the meetings of the Steering Committee and Scientific Advisory Panel of the Research Network. This support shall include transportation to meeting sites and lodging. It is expected that a program of research and development to investigate new methods, and improve existing methods, to measure and characterize the quality of genomic sequence shall also be the responsibility of the Contractor. The Contractor may be required to increase its assessment capabilities depending on the number of Sequencing Centers established during the contract term. This project is for the National Human Genome Research Institute, NIH. The estimated period of performance is three (3) years. The Government estimates that this three year period may require approximately 71,040 labor hours. This acquisition is a total small business set aside, the size standard for which is 500 employees. The Request for Proposal (RFP) will be available after 2/19/99. See Numbered Notes 1 and 26. Posted 01/27/99 (W-SN292045). (0027)

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