National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- TESTING CHEMICALS FOR ESTROGENIC ACTIVITY-POTENTIAL SOURCES SOUGHT DUE 051099 POC Jo Ann Lewis, Contracting Officer (919) 541-7894 WEB: NONE, NONE. E-MAIL: NONE, NONE. THIS IS A SOURCES SOUGHT FOR WRITTEN INFORMATION ONLY. THIS IS NOT A SOLICITATION ANNOUNCEMENT FOR PROPOSALS AND NO CONTRACT WILL BE AWARDED FROM THIS ANNOUNCEMENT. NO REIMBURSEMENT WILL BE MADE FOR ANY COSTS ASSOCIATED WITH PROVIDING INFORMATION IN RESPONSE TO THIS ANNOUNCEMENT AND ANY FOLLOW-UP INFORMATION REQUESTS. NO TELEPHONE CALLS REQUESTING A SOLICITATION WILL BE ACCEPTED OR ACKNOWLEDGED. THIS SOURCES SOUGHT MAY OR MAY NOT RESULT IN A SOLICITATION. The National Institute of Environmental Health Sciences (NIEHS) is performing a market search for contractors who can test chemicals for estrogenic activity. The tests that we are most interested in are: (1) uterotropic assay in immature female mice, (2) transcriptional activation in cultured mammalian cells using both estrogen receptor alpha and estrogen receptor beta from mice and humans, and (3) competitive binding assays with mouse alpha and beta estrogen receptors. It is not necessary that any single laboratory be capable of conducting all three types of assays. The applicable SIC Code is 8731 with a size standard of 500 employees. Interested offerors should provide information that demonstrates corporate experience in any of the following technical areas: (1) animal husbandry, toxicology, histology, and immunocytochemistry; (2) mammalian cell culture and transfection with DNA vectors, (3) biochemical analyses, and/or (4) receptor binding, scintillation counting. Additionally, interested offerors should provide information that demonstrates availability of facilities, equipment and highly competent and experienced personnel to perform the types of assays described above. ANY INTERESTED FIRM SHOULD SUBMIT A BRIEF CAPABILITY STATEMENT (maximum 3 pages) WHICH DEMONSTRATES THE FIRM'S ABILITY TO PROVIDE THE REQUIREMENT DISCUSSED ABOVE. STANDARD COMPANY BROCHURES ARE NOT DESIRED. INFORMATION SHOULD FOCUS ON THE CAPABILITY TO PROVIDE THE TECHNICAL SERVICES IDENTIFIED ABOVE. FIRMS SHALL INDICATE THEIR SIZE STATUS FOR THE ABOVE-REFERENCED SIC CODE (LARGE, SMALL, 8(a). THE DEADLINE FOR SUBMISSION OF THE CAPABILITY STATEMENT IS March 10, 1999. This document should be submitted in triplicate to Jo Ann Lewis, Contacting Officer, Research Contracts Branch, DERT, P.O. Box 12874, Research Triangle Park, NC 27613. Posted 02/24/99 (W-SN302017). (0055)

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