National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- EVALUATION OF TRANSGENIC RODENT MODELS" SOL NIH-ES-99-31 DUE 051099 POC Vondia C. Malone, Contract Specialist, (919) 541-0428,e-mail MaloneV@niehs.nih.gov, and FAX (919) 541-0428 WEB: None, None. E-MAIL: None, None. The objective of this procurement is to evaluate and characterize transgenic rodent model systems for their use as surrogates to identify carcinogens that may pose significant risk to human health. This project shall involve, but will not be limited to, the acquisition and receipt of specific transgenic or transgenic mutant or rodent strains from outside sources (including the National Institute of Environmental Health Sciences), quarantine, housing, breeding, genotyping, and maintaining the acquired rodents prior to initiating experiments. In addition, the Contractor shall have the capability to house, breed, an treat animals that are not considered to be pathogen-free. The Contractor shall be primarily responsible for the conduct of the studies based on protocols developed in conjunction with the NIEHS staff and submitted to the Project Officer for review and approval. The protocol shall be reviewed by and conform to the accepted standards for animal studies as defined in the "NIH Guide for Care andUse of Laboratory Animals." Up to eight studies may be initiated per year for a five(5) year period. A sample study protocol will be provided in the RFP. Please note that this procurement is geographically restricted. Services shall be provided by a Contractor whose facilities, equipment, personnel, and other resources are withing commuting distance to the NIEHS, Research Triangle Park (Raleigh, Durham, Chapel Hill area) due to requirements for the NIEHS scientists to obtain fresh, viable tissue for molecular biology analysis of specimen transplantation, and tissue culture research within sixty (60) minutes from the time of euthanasia. See Numbered Notes 1 and 26.***** Posted 02/25/99 (W-SN302489). (0056)

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