National Cancer Institute, Research Contracts Branch, Office of the Chief, Executive Plaza South, MSC 7222, 6120 Executive Blvd., Room 608, Bethesda, MD 20892-7222

A -- LABORATORY SUPPORT FOR GOVERNMENT SCIENTISTS WORKING AT THE FRED HUTCHINSON CANCER RESEARCH CENTER POC David M. Keefer, Contracting Officer, 301/496-8628 The National Cancer Institute (NCI) proposes to extend contract NO1-CM-65017 with the Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, for an additional two years of effort. In May 1996, NCI entered into a contract with FHCRC to support Government scientists working at the Center in their effort to evaluate a novel approach to transplanting human genes into yeast cells to develop a high through put screen for anti-cancer drugs. This model would be used for screening new potential anti-cancer agents, to study new drug targets, and to gain new insights into currently available drugs, i.e., their specific targets and mode of action. At this point in time, the screening effort has shown interesting correlations between the compounds screened and various biochemical pathways in genetically engineered yeast. This two year extension is required to continue the activities initiated under the basic contract and to pursue other interesting aspects of the screening program. This action is under the authority of 41 USC 253(c)(1), as set forth in FAR 6.302-1 and HHSAR 306-302-1. Only one responsible source and no other supplies or services will satisfy agency requirements. Interested parties may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive proposals. However, all proposals received within 45 days after publication of this synopsis will be considered by the Government. A determination by the Government not to compete this proposed extension based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. See Numbered Note 22. Posted 03/30/99 (W-SN314345). (0089)

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