National Cancer Institute, Research Contracts Branch, PCPSS, 6120 Executive Blvd, Room 635, Bethesda, MD 20892-7226

A -- EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN-VITRO TECHNIQUES SOL N01-CN-85093-63 POC Tina M. Huyck, Contracting Officer, 301-435-3830 WEB: Research Contracts and Acquisition Branch Current Requests, http://www.peacetech.com/rcab/rfps_publsihed.asp. E-MAIL: Tina M. Huyck, th38q@nih.gov. The Chemoprevention Branch of the Division of Cancer Prevention (DCP) National Cancer Institute, National Institutes of Health (NIH), is expanding the existing Master Agreement Pool for Evaluation of Chemopreventive Agents by In-Vitro Techniques. Screen and evaluate the activity of chemopreventive agents in various in vitro assays relating to the inhibition of cell transformation. Agents with potential chemopreventive activity are identified by epidemiologic surveys, initial laboratory (experimental) findings, observations in the clinical setting, or structural homology with agents having known chemopreventive activity. A rigorous and systematic evaluation of these candidate agents is necessary before their efficacy can be examined in clinical trials for cancer prevention. In vitro screening and evaluation techniques measuring the ability of these chemopreventive agents to inhibit transformation provides a relatively rapid and efficient means of qualifying these agents for further evaluation for the prevention of cancer in humans. Recent progress in the in vitro systems has led to the development of cell culture models and techniques which make possible an evaluation of the effects of various substances on cell transformation. Master Agreements will be awarded to all respondents whose technical proposal is considered acceptable. The Master Agreement award is non-monetary and is exclusively for the purpose of compiling a pool of contractors who are pre-qualified to perform services to perform Evaluation of Chemopreventive Agents by In-Vitro Techniques. Master Agreement holders receiving a contract award will be selected through this pool, based on technical merit and on budgetary considerations for specific workstatements. Any MA awarded as a result of this solicitation will be in effect from the effective date to October 30, 2002. This solicitation will be open for the duration of the existing MA pool with due dates for receipt of proposals semi-annually, August 1 and February 1 (or the next business day) of each year. All responsible sources meeting these criteria are encouraged to submit a proposal and a sample requirement to be considered by the NCI. ALL MASTER AGREEMENT HOLDERS ALREADY IN THE EXISTING MASTER AGREEMENT POOL NEED NOT RESPOND TO THIS ANNOUNCEMENT. The RFP may be accessed through the Research Contracts Branch Home Page by using the following Internet address: http://www.peacetech.com/rcab/rfps_published.asp It is the offerors responsibility to monitor the above Internet site for the release of this solicitation and amendments, if any. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. Point of contact: Tina M. Huyck, Contracting Officer, NCI, RCAB, PCPSS; 6120 Executive Boulevard, Executive Plaza South, Room 635, Rockville, MD 20852; Phone: 301-435-3830;. Fax: (301) 402-8579. Electronic mail address: th38q@nih.gov. All requests should reference the RFP No. N01-CN-85093-63. No collect calls will be accepted. See Numbered Note 26. Posted 04/05/99 (W-SN316180). (0095)

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