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B -- STUDY TO EXAMINE THE STATUS OF VITAMIN K IN A SEGMENT OF THE U.S. POPULATION SOL F63333 DUE 050399 POC Dee Gibson, Contract Administrator, (301) 827-7177 or fax (301) 827-7151 The Food and Drug Administration will issue a Request for Quotes (RFQ) for a study on Vitamin K status of nonhispanic girls and young adult women. This procurement is being conducted under the Simplified Acquisition Procedures (SAP). The Center for Safety and Applied Nutrition's (CFSAN) purpose for this requirement is to conduct a very specific measurement that is integral to its study examining the status of vitamin K in a segment of the U.S. population. The specific aims of this study are: 1) to determine the best measure of vitamin K status in a nationally representative sample of female participants in the NHANES III survey by examining the relationship between dietary vitamin K intake, serum phylloquinone, and serum levels of a functional marker of vitamin K status, the degree of under carbozylation of serum osteocalcin; and 2) to determine the influence of age and dietary intake on the nutritional status of vitamin K in this sample of girls and young adult women. The scope of work will require analysis of approximately 553 serum samples from the NHANES III survey for total serum phylloquinone levels and for the level of PIVKA II or protein in the absence of vitamin K, an under carbozylated form of the clotting factor prothrombin synthesized in the liver. Interested firms have fifteen (15) days from the publication of this synopsis to submit in writing to the identified point of contact, their request for RFQ F63333. Responses received after the fifteen days will be considered non-responsive to the synopsis and will not be considered. A determination by the Government to not compete this proposed effort on a full and open competitive basis, based upon response to this notice is solely within the discretion of the Government. Posted 04/16/99 (W-SN321434). (0106)

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