National Cancer Institute, Acquisition Management Branch, TBS, 6120 Executive Blvd, EPS/Rm 603 Bethesda, MD 20892-7220

A -- NUTRITION INTERVENTION TRIALS IN LINXIAN CHINA-CONTINUED FOLLOWUP SOL N01-SC-91030-30 DUE 060799 POC Ms. Elsa B. Carlton; Contracting Officer, (301) 435-3811 E-MAIL: Ms. Elsa B. Carlton, ec39g@nih.gov. The Cancer Prevention Studies Branch (CPSB) of the Division of Clinical Sciences (DCS), and the Biostatistics Branch (BB) of the Division of Cancer Etiology and Genetics (DCEG), National Cancer Institute (NCI) intends to negotiate with the Cancer Institute of the Chinese Academy of Medical Sciences (CICAMS) for a 1-year Fixed Price contract with four 1-year options to: (1) obtain updated endpoint data on the Nutrition Intervention Trials participants for the period June 1999 through May 2004; (2) collect and store all available diagnostic materials for Nutrition Intervention Trials participants for new cancers diagnosed during the period June 1999 through May 2004; (3) continue storage of all existing blood samples collected during the Nutrition Intervention Trials in freezers at -85 degrees Centigrade, and provide a record of daily freezer and ambient temperatures in the freezer storage room; (4) conduct a cross-sectional Nutritional Survey in a subsample of living trial participants to evaluate theirnutritional status, assess the validity of dietary questionnaires, and relate neurologic status to vitamin B12 plasma levels; (5) collect a blood sample from all trial participants who are still alive to permit further etiologic investigations of genetic and environmental hypotheses (Blood Collection Survey); (6) conduct a Vital/Cancer Status Interview Survey of all trial participants; and (7) perform Nested Case-Control Studies of selected biochemical and genetic hypotheses. The Nutrition Intervention Trials are two double-blind, placebo-controlled randomized intervention studies conducted in Linxian to evaluate multiple vitamins/minerals in the prevention of esophageal and other cancers. Beginning in 1985, the Dysplasia Trial evaluated 3318 persons with cytologic evidence of dysplasia supplemented for 6 years, while the General Population Trial evaluated 29,584 persons supplemented for 5 years. Biologic specimens were collected periodically throughout the trials and are stored at CICAMS. Post-intervention followup has continued since 1991. Because the Nutrition Intervention Trials were conducted in China by CICAMS and the blood samples are in China at CICAMS, the continued followup proposed here must be conducted in China by CICAMS. The proposed contract action is for services for which the Government intends to solicit and negotiate with only one source under authority of FAR 6.302. Numbered Note 22 applies. No collect calls will be accepted. Posted 04/19/99 (W-SN321739). (0109)

Loren Data Corp. http://www.ld.com (SYN# 0007 19990421\A-0007.SOL)