National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Bldg., Suite 7A07, 6100- Executive Blvd MSC 7510, Bethesda, MD 20892-7510

A -- RESEARCH & DEVELOPMENT CUSTOM PEPTIDE SYNTHESIS AND CONJUGATION SOL NICHD-DIR-99-01 DUE 061099 POC Charles Newman, Contract Specialist, 301-496-4611 E-MAIL: Click here to contact the NICHD Contract Specialist, cn43m@nih.gov. The National Institute of Child Health Human Development (NICHD) is looking for Capability Statements from potential contractual sources to perform PEPTIDE SYNTHESES and CONJUGATION as R&D support services for our Division of Intramural Research (DIR). The information requested in the Capability Statements will be evaluated by the NICHD Contract and Program Staff to assist in procurement planning and to develop a source list of capable contractor's that will receive a formal Request for Proposal(s), assuming the NICHD decides to pursue procurement of these services. Potential contractual sources capable of performing these services are encouraged to submit Capability Statements at this time. The following is a more detailed description of the capabilities sought by the NICHD: A. CUSTOM PEPTIDE SYNTHESIS & CONJUGATION PROCEDURES: 1. Potential contractual sources should provide documentation that they can provide custom synthesis of biologically active peptides meeting the following specifications: a. Synthesis of custom peptides of 3 to 80 amino acids in length; b. Synthesis of peptides containing phosphoryl and sulfonated amino acids; c. Multiple antigenic peptide synthesis. Multiple attachment of peptide to polylysine. Ref. D.N. Posnett, H. McGrath and J.P. Tam, J. Biol. Chem 263:1719, 1988; d. Contractor shall be prepared to provide government with custom peptides in lot sizes of 5 mg, 10 mg. 15 mg. 25 mg. or 100 mg.; e. Peptides may be requested as unpurified, or to a purity to exceed >80%, >90%.; f. Quality assessment of each preparation shall include HPLC, amino acid analysis and mass spectrometry. 2. Conjugation Procedures: a. Potential contractual sources should provide documentation that they can provide services for the conjugation of peptide or antigen to KLH, BSA or Ovalbumin using MBS, carbodiimide or glutaraldehde reagent procedures. Capability Statements must be submitted, by the date indicated, to Mr. Charles Newman, Contracting Specialist, at the above address. There isno required Standard Form or prescribed format for the Capability Statement. However, in addition to the information requested above, your Capability Statement should include details specifying how the work would be performed, details on experience with similar projects and information on whether your organization is a small business concern. While at this time the NICHD is not asking for proposed prices for performing this work, information on pricing methodologies and information on whether your organization routinely provides these services to private commercial (non-government) sources is encouraged. Please note, there is NO Request for Proposal(s) or formal solicitation associated with this synopsis and the government reserves the right to cancel all requirements at any time. Posted 04/22/99 (W-SN323471). (0112)

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