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66 -- HIGH-FIELD, MULTI-NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROMETER SOL 1999Q9764 POC Darien DiCamillo, Contract Specialists, Phone(202) 433-2051 Desc: FISC NORFOLK DET WASHDC intends to issue a request for quotation (RFQ) for a HIGH-FIELD, MULTI-NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROMETER. The RFQ shall include the following: de-installation of existing spectrometer; delivery, installation, and maintenance of the new spectrometer; warranty; training, operating software and manuals. Offers shall only be accepted from prospective offerors that allow government mandatory site visit for demonstration of spectrometer capabilities. Any interested parties shall respond immediately after publication of this synopsis in order to arrange for the mandatory site visit. Specifications for the new spectrometer are as follows: a. The completely new, high-field (400 MHz), multi-nuclear spectrometer must be capable of observing a wide-range of NMR active nuclei, including but not limited to 1H, 2H, 13C, 15N, 19F and 31P. The entire spectrometer system must be a state-of-the-art, currently commercially available instrument. It must be supplied by a vendor of national and international reputation and recognition, having been in the NMR spectrometer development, manufacture, and service business. The spectrometer must be supplied as a liquid-analysis system, capable of future modifications and enhancements (in hardware and software) to allow for the analysis of solid samples, while retaining the primary capability of liquid sample analysis. b. The spectrometer must be able to perform multiple tasks including, but not limited to, routine data analyses, homonuclear decoupling experiments, Broad Band (BB) decoupling experiments, and variable temperature (VT) studies. In addition to the types of tasks which the spectrometer can perform, it must also be multi-tasking in its operation, capable of simultaneous data acquisition with data analysis and/or data transfer. The basic operating software should be supplied as a pre-loaded package on the spectrometer, yet the software should be flexible enough to allow for the system operator to program the instrument for a customized experiment. c. The spectrometer must be able to execute two-dimensional analytical studies including but not limited to COSY, NOSY, ROSEY, HETCOR, COLOC, HMQC, and HMBC. The pulse-sequencing programs for these two-dimensional analytical studies should be pre-packaged within the system software provided with the spectrometer at the time of delivery. The software, however, should be designed in such a manner as to allow the spectrometer operator to modify the parameters of the pulse-sequence programs for specialized experiments and to write new pulse-sequence programs. Sufficient computer program storage space must be available on the purchased spectrometer to allow for the addition of new or modified operating programs and pulse-sequence programs as they are supplied by the system manufacturer or developed by the customer. The spectrometer should have sufficient computer capability and flexibility to allow for the addition of three-dimensional analysis programs as they become available from the manufacturer, commercial vendors or other NMR users. d. The instrument must be evaluated as "user-friendly" (as defined by the customer), with easy-to-use icon and drop-down menu type software (e.g., Windows -driven). The automated software should be sufficiently clear in its construct to allow for the routine use of the spectrometer by undergraduate students, while sufficiently sophisticated in design to support the analytical needs of research faculty. e. The NMR spectrometer must operate as a stand-alone instrument, with the system design sufficiently modern and versatile to allow for an easy network connection via ethernet and using 10Base-T connectors. All hardware and software components should be of such a design as to allow for easy upgrade and maintenance. A-2. The instrument must have the following features as a minimum. 1. It must be a 400 MHz frequency instrument with an internal deuterium lock. 2. It must have a superconducting cryomagnet operating at 9.4 Tesla. 3. It must have a 52 mm or a 54 mm bore size magnet. 4. It must include a shielded Oxford dewar magnet or a shielded SPECTRASPIN dewar magnet, with a minimum hold time of 180 days for liquid helium. The minimum hold time must be 9 days for liquid nitrogen. The field drift of the magnet system must not exceed 8 Hertz per hour. 5. As a minimum, the installed magnet system must be equipped with 9 cryoshims and 17 room temperature shims. 6. The instrument, as delivered, must include the required shim systems necessary to perform high quality inverse detection experiments. 7. The magnet system shall be stabilized with an anti-vibration platform, legs or posts system. (Anti-vibration tires are not acceptable.) The anti-vibration system supplied as part of the spectrometer must be properly positioned when the magnet is initially installed in the designated location at the U.S. Naval Academy. 8. The dewar-magnet system must have an internal metering system for monitoring the level of the liquid helium and liquid nitrogen cryogens, and the recorded measurement must be displayed as a digital readout or via a metered indicator at the instrument console. (An externally introduced probe is not acceptable.) 9. The instrument must have a microprocessor controlled variable temperature unit operating at 110 volts. The VT microprocessor unit must contain state-of-the-art technology, with a minimal operating range of -150 oC to +180 oC. The VT system must have a minimal degree of accuracy of 0.1 oC, as calibrated via computer-controlled programs. 10. The instrument must be supplied with the appropriate external cryogen dewar system, gas feed lines and gas inlets required for the operation of the variable temperature unit in low and high temperature conditions. 11. The instrument must be equipped with a quadrature phase detection system. 12. A homo-/heteronuclear, computer-controlled 1H decoupler must be supplied as part of the instrument. 13. The instrument must be supplied with two 5 mm spinners. Both spinners are to be made of either a ceramic or composite material. 14. The manufacturer must supply all process controllers necessary for controlling the spectrometer, for generating the pulse sequences, and for pulse decoupling programs, etc. 15. Each probe supplied must be of state-of-the-art design technology. Each probe must be new and must be of such a design as to allow for easy and rapid extraction and insertion of the probe within the magnet. The majority of the set-up and measurement by the probe must be controlled by the instrument computer system. The instrument must be supplied with the following probes: Broad Band Observe with Z -- gradient with 1H Decouple, 1H/15N -- 31P, 5 mm, VT capable, with the following specifications: S/N: 1H 200:1 (.1% ethylbenzene); 13C 130:1 ASTM, Resolution: 0.25 Hz, 90 pulse: < 15 msec; Inverse Broad Band, 1H/15N -- 31P, 5 mm, VT capable, with the following specifications: S/N: 1H 400:1 (.1% ethylbenzene); 13C 130:1 ASTM, Resolution: 0.25 Hz, 90 pulse: < 15 msec; 19F Observe/ 1H Decouple, 5 mm, VT capable, with the following specifications: S/N: 1H 300:1 (1% ethylbenzene); 19F 200:1 (1% F-113), Resolution: 0.25 Hz, 90 pulse 1H: < 30 msec. 16. As a minimum, the instrument must be supplied with the following computer, monitor, printer, and software system. Computer : The host workstation supplied with the instrument must be a Silicon Graphics O2 workstation utilizing the 64-bit R5000 processor (or better), operating at 180 MHz (or higher). It must be equipped with 64MB (or greater) memory, a 9 GB (or larger) system (hard) disk, a 32X CD-ROM drive, a ZIP drive, and 10Base-T/100Base-TX ethernet networking hardware. Other standard items (keyboard, mouse, cables, etc.) must be included. monitor: The workstation monitor must be a color monitor, with 17" (or larger) screen and 1280 x 1024 (or better) resolution. Cables must be supplied. printer: The system must include a HP LaserJet Postscript printer/plotter (or equivalent). The printer must be HP6X or newer. Cables must be included. workstation software: The system must include the UNIX operating software for the host workstation, IRIX 6.x or newer. It must be a commercially available version of the software, not a "beta" test version. It must also include any appropriate software to support TCP/IP and Windows networking, and any required software to support interchange of ZIP disks between Windows and UNIX platforms. 17. The instrument must be supplied with all required chassis, cabinets, cables, connectors, cryogen transfer lines, etc., as required to make the system operational. 18. The manufacturer must provide, at no additional cost and for as long as necessary, any requisite power supply necessary to activate the system and to bring the magnet to field on initial installation. 19. For on-site operation of the spectrometer: The manufacturer must supply two copies of each data and file transfer program, as developed by the manufacturer and required for the spectrometer system to operate. These copies should be supplied in electronic format, as an appropriate removable medium, and supporting documentation for the use of each of these programs should be provided in printed format. 20. To allow for post-acquisition processing and manipulation of the NMR data at remote sites away from the spectrometer: The NMR system vendor must supply two copies of the manufacturer's developed or recommended spectra analysis programs for PC-based systems. These copies should be supplied in electronic format, as an appropriate removable medium, and supporting documentation for the use of each of these programs should be provided in printed format. The Government intends to acquire a commercial item using FAR Part 12 and Simplified Acquisition Procedures FAR Part 13.5. Oral communications are not acceptable in response to this notice. All responsible sources may submit a request for an RFQ. The Government intends to award a firm-fixed price contract to the responsible offeror conforming to the items listed herein and in the RFQ considered to be most advantageous to the Government. Additional specs will be forwarded with RFQ. Award will be on an all-or-non basis with respect to the requested supplies and services. Posted 05/06/99 (W-SN328762). (0126)

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