Centers for Disease Control and Prevention (CDC), Procurement and Grants Office, FCC & E Section, Mailstop (K-71), 2920 Brandywine Road, Atlanta, GA 30341-4146

66 -- DOUBLE FOCUSING MAGNETIC SECTOR HYBRID MASS SPECTROMETER SOL 1999N00082 DUE 052799 POC William Bancroft, Contract Specialist, (770) 488-2611 This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The Solicitation Number is 1999N00082 and is issued as a Request for Proposal (RFP). The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The solicitation and incorporated provisions and clauses are those in effect through Federal Acquisition Circular 97-08. This procurement is UNRESTRICTED. The Standard Industrial Classification Code (SIC) is 3829. The small business size standard is no more than 500 employees. DESCRIPTION OF THE ITEM REQUIRED: Provide one (1) double foucusing magnetic sector hybrid mass spectrometer in accordance with the following design and performance Specifications. The mass spectrometer system must be capable of high resolution MS and be capable of MS/MS by high resolution selection of a precursor ion in the first MS, collision induced dissociation (CID), and the analysis of the product ions in the second MS: I. DESIGN SPECIFICATIONS: (1) The Magnetic Sector Hybrid Mass Spectrometer System shall include: (a) at least one electric sector and one magnetic sector with double focusing ion optics; (b) At least a 4000 Da mass range at full accelerating potential. The full accelerating potential must be at least 5 kV; (c) Positive and negative ion facilities; (d) Dedicated EI and CI ion sources; (e) Electrospray (ESI), atmospheric pressure chemical ionization (APCI), and liquid secondary ion MS ion sources (f) First field free region collision gas cell; (g) Computer controlled continuously variable slits; (h) 20 kV off-axis dual-dynode with either an electron or photo multiplierdetector; (i) Vacuum system including: at least one Diffstak pump or turbomolecular pump for the source region. At least two Diffstak or turbomolecular pumps for the analyzer region. (j) a second mass spectrometer in tandem with the magnetic sector mass spectrometer which is composed of either a time of flight MS, ion trap MS or second magnetic sector MS.(k) An efficient collision cell or quadrupole that can be filled with gas to perform CID. (l) Integrated analyzer baking and anti-vibration facilities; (m) Isolation transformers; (n) Mass Spectrometer/Data System interface hardware with Mass Spectrometer Software and Users License (o) One set of instruction manuals and schematic diagrams. (2) Direct insertion probe and vacuum interlock (water-cooled shaft programmable in temperature from 100 degrees C to 450 degrees C). (3) Heated septum inlet for introduction of volatile compounds. (4) HP 6890 or equivalent GC (split/splitless with EPC), integrated HPIB interface, and transfer line including: (a) Split/splitless and cold on-column automatic injectors and sampler; (b) Pneumatic and temperature control; (c) RS232 interface for MS Data System Control of GC also must be able to communicate to HPLC; (d) installation kit with column and consumable supplies; (e) Heated direct interface for two capillary GC lines. (5) Tuition for one five-day training course at MS training facility. (6) Mass Spectrometer Data System Hardware including: (a) DEC 433 MHz Alpha Workstation with: DEC Alpha CPU (210 SPECfp92); DEC Open VMS/Motif or Digital Unix operating system with appropriate DEC graphics; and a minimum of 128 Megabytes of RAM; DEC mouse cursor and US keyboard; Hardware technical documentation. The offeror should also include options for PC based data systems and software. (b) DEC 21" high resolution color monitor. (c) a minimum of two 4.3 Gigabyte fixed disk or equivalent fixed disk drive. (d) DEC 1.44 Megabyte floppy disk drive. (e) DEC TLZ09 8.0 Gigabyte DAT archival system. (f) DEC minimum 600 Megabyte double-speed CD-ROM disk drive. (g) DEC Laser LN17 ppm 600 dpi Laser Printer/Plotter (including 4 Megabyte RAM upgrade) or Hewlett Packard laser Jet 5SI or equivalent postscript laser printer/plotter. (h) Open VMS media or Digital UNIX V4.0D (CD-ROM) and appropriate networking software, hardcopy documentation, and an option for single user or site license. (i) DCPS License and 12 month Digital software support. (j) Two Ethernet communications adapters (AUI, 10base2, 10baseT) and NAS150 license. (7) 1.2 Gigabyte Rewriteable Optical Disk Drive (600 Mbyte per side); (8) An option to purchase either a Leap CTC Model A200SE Automatic Injector/Sampler with adaptor plate for HP 6890 GC or an HP 7683 autosampler with parts that are compatible to a HP6890 GC; Both autosamplers must be controlled from the mass spectrometer data system.(9) Spare Inner EI Ion Source. 10) The system should have an ultimate resolution of 60,000 (10% valley definition)to ensure sensitivity at elevated resolution. 11) Off line processing software should also be available for both PC and Alpha workstations and must include capabilities for direct copy and paste of graphical and tabular data into standard worksheets and word processing software. The off-line processing software must also support full quantification processing from high resolution data according to established protocols EPA 8290/1613. The software must include protein analysis and deconvolution. 12) An option to purchase an array detector for the magnetic sector MS. SPECIFIC INSTRUMENT SYSTEMS: (1) Gas Chromatograph; (2) GC/MS Interface; (3) API interfaces (4) Inlets and Accessories (5) Ion Source Facilities; (6) Tandem Mass Spectrometers; (7) Vacuum System; (8) Electronics and Data System. II. PERFORMANCE SPECIFICATIONS: (a) At 1000 resolution in EI mode, observing methyl stearate at m/z 298.3, the mass Spectrometer should give an ion current of at least 5 x 10-7 coulombs/ug. (b) At 10,000 resolution in EI mode, observing methyl stearate at m/z 298.3, the Mass Spectrometer should give an ion current of at least 5 x 10-8 coulombs/ug. (c) At 1000 resolution in positive CI mode, observing methyl stearate at m/z 299.3, the Mass Spectrometer should give an ion current of at least 5 x 10-8 coulombs/ug. (d) At 1000 resolution in negative ion CI mode, observing anthraquinone at m/z 208, the Mass Spectrometer should give an ion current of at least 5 x 10-8 coulombs/ug. (e) 200 pg of methyl stearate in GC EI mode and 1 sec/decade scanning should give a signal:noise of at least 400:1 for the m/z 298.3 ion. (f) In GC mode, at 5,000 resolution and 0.5 sec/decade, 10 ng of methyl stearate injected onto a capillary column should give an RMS mass error of less than 2 mmu on averaged data. This value is calculated between the experimental and actual masses of all hydrocarbon peaks above mass 70 with at least 0.5% intensity of the base peak (at m/z 64). (2) Performance specifications for small molecules, peptides and proteins shall be included. (A) Specification for positive ion APCI on cotinine for full scan, SIM MSand MS/MS. (B) Specifications for negative ion full scan MS, SIM MS and MS/MS on para-nitrophenol. (C) Specification for positive ion ESI full scan MS, SIM MS and MS/MS on Substance P, Leucine Enkephalin, and cotinine. (D) Specifications for GC/MS on methyl Eugenol. (E) Protein analysis by positive ion ESI MS on hemoglobin samples showing both HbAo and HbA1c peaks. Other important considerations: A) The Mass Spectrometer needs to be capable of AUTOMATION and show OVERNIGHT UNATTENDED OPERATION. B) A key requirement is the integration of data from the mass spectrometer data system into the existing data processing environment at CDC. Offeror must address how their data system will work with the automated logbook, quantitation, Rbase data base and SAS programs currently in use at CDC. C) Offeror must discuss ESI deconvolution and protein analysis software. D) Offeror must discuss and propose time and plan to train personnel to required level of operator competence. A plan for continued training should also be included. D) Offeror shall also provide names and contact information of all organizations that have purchased the mass spectrometer in the past two years, including five (5) laboratories in the United States where this mass spectrometer has been operating for at least one year. F) The contractor shall provide full warranty coverage for the instrument for a one year period after installation. G) The contractor shall provide on-site training in the operation of the equipment following installation (a minium of 5 days after installation is complete). H) Samples for further evaluation can be provided for further evaluation for mass spectrometers that meet the above requirements. Technical merit and past performance, when combined, are significantly more important than cost or price. Evaluation of technical merit will include whether the offeror has demonstrated compliance with the stated requirements as well as flexibility of design, over-engineering with a view to support future enhancements and demonstration of quality of analytical results. The provision at FAR 52.212-1, Instructions to Offerors -- Commercial Items is applicable without addenda. The provision at FAR 52.212-2, Evaluation -- Commercial Items is applicable. Technical merit and past performance, when combined, are significantly more important than cost or price. Evaluation of technical merit will be based on technical capability of the item offered to meet the Government requirements. Offerors must include a completed copy of the provision at FAR 52.212-3, Offeror Representations and Certifications -- Commercial Items. The clause at 52.212-4, Contract Terms and Conditions -- Commercial Items is applicable. The following additional terms and conditions are included by addenda: FAR 52.214-34, Submission of Offers in the English Language (APR 1991); FAR 52.214-35, Submission of Offers in U.S. Currency (APR 1991); FAR 52.246-17, Warranty of Supplies of a Complex Nature (APR 1984). The clause at FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders -- Commercial Items applies to this action. The following FAR clauses cited within FAR 52.212-5 are applicable: 52.203-6, Restrictions on Subcontractor Sales to the Government, Alternate I; FAR 52.219-8 Utilization of Small Business Concerns and Small Disadvantaged Business Concerns; FAR 52.219-23, Notice of Price Evaluation Adjustment for Small Disadvantaged Business Concerns, Alternate I (OCT 1998); FAR 52.222-26, Equal Opportunity; FAR 52.222-35, Affirmative Action for Disabled Veterans and Veterans of the Vietnam Era (APR 1998); FAR 52.222-36, Affirmative Action for Workers with Disabilities (JUN 1998); FAR 52.222-37, Employment Reports on Disabled Veterans and Veterans of the Vietnam Era (APR 1998); FAR 52.225-3, Buy American Act-Supplies (JAN 1994); FAR 52.225-18, European Union Sanction for End Products (JAN 1996). Offerors shall use the Standard Form 1449, "Solicitation/Contract/Order for Commercial Items" form found at URL: http://www.arnet.gov/far/. Offers must show (1) The solicitation number 1999N00082; (2) The name, address, and telephone number of the offeror; (3) A technical description of the items being offered in sufficient detail to evaluate compliance with the requirements in the solicitation; (4) Warranty terms; (5) Price for each line item and "total price" including all applicable costs (sales tax, etc.). (6) "Remit" to address if different than mailing address; (7) Completed copy of the representations and certifications at FAR 52.212-3; (8) Past performance information to include recent and relevant contracts for the same or similar items and other references (including contract numbers, points of contact with telephone numbers and other applicable information. Delivery shall be made FOB Destination within one hundred fifty (150) days of contract award. Delivery and installation shall be made to 4770 Buford Highway, N.E., Building 17, Loading Dock, Atlanta, Georgia 30341-3724. Acceptance shall be at 4770 Buford Highway (Chamblee Campus), upon completion of installation, demonstration and training. Payment terms are 80% upon completion on installation and demonstration of compliance with specifications, and 20% upon completion of training. Proposals are due at 2:00 PM, May 27, 1999, to the following address: Centers for Disease Control and Prevention, Contracts Management Branch Atlanta, 2920 Brandywine Road, Atlanta, Georgia 30341-4146. For information regarding this solicitation, contact Bill Bancroft at (770) 488-2611 All responsible sources may submit an offer. No telephone requests for the solicitation package will be accepted.**** Posted 05/06/99 (I-SN328437). (0126)

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