National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

A -- CORONARY ARTERY DISEASE RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY SOL RFP NHLBI-HC-98-36 DUE 071999 POC William M. Stevens, Contracting Officer; (301) 435-0345, fax (301) 480-3430. WEB: http://www.nhlbi.nih.gov/nhlbi/rafs/rfas.htm#rfp, http://www.nhlbi.nih.gov/nhlbi/rafs/rfas.htm#rfp. E-MAIL: ws69s@nih.gov, ws69s@nih.gov. The National Heart, Lung, and Blood Institute has a requirement for 1 Computed Tomography Reading Center (CTRC) to read scans performed as part of the renewal CARDIA study. CARDIA is a longitudinal cohort study designed to assess the development of CVD in men and women initially aged 18-30 years in four U.S. communities. In its year 15 examination, the study will assess measures of subclinical disease, or disease detected non-invasively before it has produced signs and symptoms. The proposed renewal of the CARDIA Study has four primary objectives: 1. Measure early atherosclerosis, using noninvasive means, in persons aged 33-45. 2. Identify and quantify risk factors for the early development of atherosclerosis measured noninvasively. 3. Identify and quantify gene-environment interactions that contribute to the development of cardiovascular risk factors and to early atherosclerosis. 4. Determine whether significant race or gender differences exist in the risk factors for early atherosclerosis or in the gene-environment interactions that lead to the development of atherosclerosis. The CARDIA CTRC will coordinate, at the direction of the Steering Committee and in collaboration with the Coordinating Center and Field Centers, the development of protocols for computed tomography (CT) examinations for coronary calcium at each Field Center, and CT reading and information abstraction at the Reading Center, in accordance with the study design. Train and certify Field Center technicians according to the scanning protocol. Train and certify CT readers at the Reading Center according to the reading and information abstraction protocol. Conduct a pilot test of the CT protocols, including Quality Control activities, during the protocol development/pilot testing phase, in collaboration with Field Centers and the Coordinating Center. Perform readings and information abstractions of CT measurements on approximately 3,320 studies during the 12-month examination period. It is expected that 3,890 CARDIA participants will undergo the Year 15 examination and that 80% (3,112) will undergo CT examinations during the 12-month examination period, from June 1, 2000 to May 31, 2001. Plan for a pilot study to include approximately 10 scans per site. Plan to reread all scans by the same and by a second reader for 5% rereads by a second reader. A cost-reimbursement contract will be awarded for 3 years and 11 months. This is not the Request for Proposals (RFP). RFP No. NHLBI-HC-98-36 will be released on or about May 28, 1999 on the NHLBI contracts web page at http://www.nhlbi.nih.gov/nhlbi/rafs/rfas.htm#rfp. There are no paper copies. Interested organizations should review and download the streamlined RFP designated as RFP # NHLBI-HC-98-36 which will appear under the list of RFPs for the National Heart, Lung, and Blood Institute. Further instructions and forms for proposal submission are located at the menu selection entitled "Streamlined RFP References" which is located at the web page for the NIH Request For Proposals Directory, http://www4.od.nih.gov/ocm/contracts/rfps/mainpage.htm. This proposed program is not set aside for small business vendors; the SIC Code is 8731. (Click here to download a copy of the RFP. URL: http://www.nhlbi.nih.gov/nhlbi/rafs/rfas.htm#rfp ) (Click here to contact the contracting officer via e-mail. EMAIL: ws69s@nih.gov ) Posted 05/12/99 (W-SN330547). (0132)

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