National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Bldg., Suite 7A07, 6100- Executive Blvd MSC 7510, Bethesda, MD 20892-7510

A -- CONTINUED DEVELOPMENT AND TESTING OF A NEW SPERMICIDE/VIRICIDE COMPOUND!! SOL N/A!! POC Contact Mr. Robert Stallings, Contract Specialist, 301/435-6965 The National Institute of Child Health and Human Development, National Institutes of Health, is planning to award a contract to Biosyn, Inc. for research involving a compound which has demonstrated potent in vitro antiviral, antibacterial, and spermicidal properties. Subject to satisfactory results in two ongoing clinical trials of the compound in humans, the compound will be considered for a Phase II contraceptive efficacy study. The proposed contract will involve teratology, toxicology, and other studies which must be performed prior to the Phase II trial as well as identification, quantification, and characterization of metabolites to be performed concurrent with the Phase II trial. The Government and Biosyn, Inc. have invested considerable time and resources to bring the compound to its current state of development and Biosyn, Inc. hold the exclusive rights to manufacture the compound as well as the Investigational New Drug approval for clinical development. See Note 22. Posted 06/29/99 (W-SN348394). (0180)

Loren Data Corp. http://www.ld.com (SYN# 0010 19990701\A-0010.SOL)