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COMMERCE BUSINESS DAILY ISSUE OF AUGUST 6,1999 PSA#2404National Institutes of Health, National Institute of Allergy and
Infectious Diseases, Contract Management Branch, Room 2230, 6700-B
Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612 A -- TISSUE-BASED SMALL ANIMAL MODEL FOR HIV DRUG DISCOVERY SOL
NIH-NIAID-DAIDS-00-20 DUE 110199 POC Carl Henn, Contract Specialist,
(301) 496-0993 The National Institute of Allergy and Infectious
Diseases (NIAID) supports a comprehensive portfolio of contract
resources to discover and develop novel therapeutic agents for the
prevention and treatment of infections caused by Human Immunodeficiency
Virus-1 (HIV-1), AIDS-associated opportunistic pathogens, and other
infectious agents. Animal model resources constitute one element of
this drug discovery and development program. The purpose of the present
RFP is the competition of a small animal model that can be used to
evaluate potential therapeutics for HIV-1 infection. The contractor
will be responsible for i) evaluating therapeutic agents, alone and in
combination, for efficacy and toxicity in vitro and in the SCID-hu
thymus/liver animal model; ii) performing quality assurance/control of
the components of the in vitro and in vivo assay systems, to insure
reproducible evaluation of candidate therapies; iii) determining
optimal routes and schedules of administration; iv) modifying the model
system as necessary, to augment its usefulness for evaluating potential
HIV-1 therapeutics; and 5) preparing and submitting periodic and
interim reports. The current contract utilizes the following material
in performance of the contract: up to 100 SCID-hu thymus/liver mice per
month, in groups of 50 engrafted with tissue from a single donor. This
minimum capacity is required. It is anticipated that one (1) cost
reimbursement, completion type contract will be awarded for a period of
seven (7) years, beginning approximately June 1, 2000. RFP
NIH-NIAID-DAIDS-00-20 will be available electronically on or about
August 19, 1999, and may be accessed through the NIAID Contract
Management Branch (CMB) Home Page by using the following electronic
address and instructions: NIAID/CMB Home Page (via the WWW): Use
http://www.niaid.nih.gov/contract to access the NIAID/CMB Home Page.
Once at the NIAID/CMB Home Page, click on the "RFPs" link and then
click on "RFP NIH-NIAID-DAIDS-00-20." Please note that the RFP for this
acquisition has been revised to include only the Work Statement,
Deliverable and Reporting Requirements, Special Requirements, the
Technical Evaluation Criteria, and the Specific RFP Instructions and
Provisions. All information required for the submission of an offer
will be contained in the electronic RFP package. The government intends
to make award without discussions. Responses to this RFP will be due on
November 1, 1999. Any responsible Offeror may submit a proposal which
will be considered by the Government. This advertisement does not
commit the Government to award a contract. Point of Contact: Carl Henn,
Contract Specialist Electronic mail address: ch24v@nih.gov Telephone:
(301) 496-0993 FAX: (301) 480-5253 No collect calls will be accepted.
Posted 08/04/99 (W-SN363274). (0216) Loren Data Corp. http://www.ld.com (SYN# 0004 19990806\A-0004.SOL)
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