National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- TISSUE-BASED SMALL ANIMAL MODEL FOR HIV DRUG DISCOVERY SOL NIH-NIAID-DAIDS-00-20 DUE 110199 POC Carl Henn, Contract Specialist, (301) 496-0993 The National Institute of Allergy and Infectious Diseases (NIAID) supports a comprehensive portfolio of contract resources to discover and develop novel therapeutic agents for the prevention and treatment of infections caused by Human Immunodeficiency Virus-1 (HIV-1), AIDS-associated opportunistic pathogens, and other infectious agents. Animal model resources constitute one element of this drug discovery and development program. The purpose of the present RFP is the competition of a small animal model that can be used to evaluate potential therapeutics for HIV-1 infection. The contractor will be responsible for i) evaluating therapeutic agents, alone and in combination, for efficacy and toxicity in vitro and in the SCID-hu thymus/liver animal model; ii) performing quality assurance/control of the components of the in vitro and in vivo assay systems, to insure reproducible evaluation of candidate therapies; iii) determining optimal routes and schedules of administration; iv) modifying the model system as necessary, to augment its usefulness for evaluating potential HIV-1 therapeutics; and 5) preparing and submitting periodic and interim reports. The current contract utilizes the following material in performance of the contract: up to 100 SCID-hu thymus/liver mice per month, in groups of 50 engrafted with tissue from a single donor. This minimum capacity is required. It is anticipated that one (1) cost reimbursement, completion type contract will be awarded for a period of seven (7) years, beginning approximately June 1, 2000. RFP NIH-NIAID-DAIDS-00-20 will be available electronically on or about August 19, 1999, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page by using the following electronic address and instructions: NIAID/CMB Home Page (via the WWW): Use http://www.niaid.nih.gov/contract to access the NIAID/CMB Home Page. Once at the NIAID/CMB Home Page, click on the "RFPs" link and then click on "RFP NIH-NIAID-DAIDS-00-20." Please note that the RFP for this acquisition has been revised to include only the Work Statement, Deliverable and Reporting Requirements, Special Requirements, the Technical Evaluation Criteria, and the Specific RFP Instructions and Provisions. All information required for the submission of an offer will be contained in the electronic RFP package. The government intends to make award without discussions. Responses to this RFP will be due on November 1, 1999. Any responsible Offeror may submit a proposal which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of Contact: Carl Henn, Contract Specialist Electronic mail address: ch24v@nih.gov Telephone: (301) 496-0993 FAX: (301) 480-5253 No collect calls will be accepted. Posted 08/04/99 (W-SN363274). (0216)

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