National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

A -- THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL PHS 2000-1 DUE 110599 POC Office of Extramural Programs, Office of Extramural Research, (301) 435-2770 WEB: NIH Small Business Funding Opportunities home page, http://www.nih.gov/grants/funding/sbir.htm. E-MAIL: PHS SBIR/STTR Solicitation Office, a2y@cu.nih.gov. THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) PROGRAM OF THE U.S. PUBLIC HEALTH SERVICE SOL [PHS 2000-1] DUE 110599 POC Office of Extramural Programs, Office of Extramural Research, (301) 435-2770. National Institutes of Health, Bethesda, MD 20892 and Centers for Disease Control and Prevention, Atlanta, GA 30305 are soliciting proposals from small business concerns that possess the research and development (R&D) expertise to conduct innovative research that will contribute toward meeting the program objectives of the agencies. A SOLICITATION OF THE PUBLIC HEALTH SERVICE FOR SMALL BUSINESS INNOVATION RESEARCH CONTRACT PROPOSALS [PHS 2000-1], with a closing date of November 5, 1999, for receipt of proposals, will be available electronically in late August or early September through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Included in the Solicitation is a "Fast-Track" initiative. Fast-Track is a parallel review option available to those small business concerns (offeror organizations) whose proposals satisfy additional criteria which enhance the probability of the project's commercial success. Fast-Track offers two major advantages: (1) concurrent peer review of both Phase I and Phase II projects and (2) minimal or no funding gap between Phase I and Phase II. A "Product Development Plan Appendix" must accompany the Phase II proposal. The SBIR program, which was initiated in 1982, was reauthorized through fiscal year 2000 by the "Small Business Research and Development Enhancement Act of 1992" (Public Law 102-564, dated October 28, 1992). The purposes of the Act are to: (a) expand and improve the SBIR program; (b) emphasize increased private sector commercialization of technology developed through federal R&D; (c) increase small business participation in federal R&D; and (d) foster and encourage participation of socially and economically disadvantaged small business concerns and women-owned small business concerns in the SBIR program. For purposes of the SBIR program, a "small business concern" is any business concern that: (a) is independently owned and operated; (b) is not dominant in the field of operation in which it is proposing; (c) has its principal place of business located in the United States; (d) is organized for profit; and (e) has, including its affiliates, no more than 500 employees. Following are the research topics identified in the PHS SBIR Contract Solicitation [PHS 99-1]: NATIONAL INSTITUTES OF HEALTH (NIH) -- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM (NIAAA): Development of Methodology for Measuring Compliance for Medications; Medications Development; Evaluation of Alcohol Abuse and AIDS Prevention Programs; Performance Indicators of Quality of Care for Alcohol Treatment; Registry for Fetal Alcohol Syndrome; Science Education Materials Development for Middle Schools or High Schools; NATIONAL CANCER INSTITUTE (NCI): In Vitro Toxicity Evaluation of AntiCancer Agents; Develop Models to Enhance the Quality of Interactive Health and Medical Information; Guidelines for Developers and Users for Interactive Health and Medical Information; Chemical Diversity-Based Methods Identifying New Tumor Markers or Probes; Encoding Surgical Pathology Data into Standard Nomenclature within XML; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK): Assays for Identification of High Risk Individuals for the Development of Insulin Dependent Diabetes (IDDM); Transplantation of Human Islets or Beta Cells; Improved Methods for Production of Clinical Gene Therapy Vectors for Diseases of Interest to NIDDK; Acute Renal Failure; New Noninvasive Body Iron Test; Mechanical Approaches to Achieving Euglycemia; Chronic Renal Failure; Measurement of Pancreatic Beta-Cell Mass or Inflammation in the Diabetic Patient; Generation of cDNA Libraries from Hematopoietic Lineages; Development of Arrayed Libraries and Bio-informatics for Use in cDNA Microarrays; NATIONAL INSTITUTE ON DRUG ABUSE (NIDA): Drug Supply Services Support; Chemical Libraries for Drug Development; Analytical Techniques Program; Computerized Neuropsychological Testing Software; Development of Improved HIV Risk Behavior Questionnaire and Interview; Develop Prevention Research Dissemination; Design and construction of a multi environment, multi choice rodent testing apparatus; Measurement Modules for Prevention Interventions; Web-based Visualization and Analysis of DNA Micro-Array Data; Kits for DNA Micro-array Technology; Antibodies for Neuroscience Research; Telemedicine; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES (NIEHS): Development of Effective Mitigation Methods or Devices for Reduction of Indoor Dust Mite Allergens; Development of Effective Mitigation Methods or Devices for Reduction of Indoor Cockroach Allergens; Construction of Xenopus cDNA Gene "chips" for Analysis of Gene Expression; Development and Use of Large Scale in situ Hybridization Histochemistry Techniques to Examine Gene Expression Profiles in Early Xenopus Embryos; Use of Gene Chip Arrays to Analyze Expression Patterns of mRNA in Knockout Mice; NATIONAL HEART LUNG, AND BLOOD INSTITUTE (NHLBI): Wireless Telemetry of EKG and Respiratory Information from within an MRI Scanner; NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS): NIRS Device Development for Cerebral Monitoring in the Infant and Child; Neuroimaging in HIV Infection; Development of Systems to Express Functional Eukaryotic Membrane Proteins For Crystallization; Development of Pain Model Systems and Assessment Tools; Novel Therapy for Sleep and Circadian Disorders; Improved Methods and Standardization for Rodent Neurophysiological Recording; NATIONAL CENTER FOR RESEARCH RESOURCES (NCRR): Software for Managing Data from Data-Intensive Biomedical Instruments; CENTERS FOR DISEASE CONTROL AND PREVENTION (CDC) -- National Immunization Program (NIP): Needle-free Devices or Technologies to Administer Measles Vaccine; Assay to Detect Picoliter Blood Quantities as Surrogate for Minimal Infectious Doses of Blood-borne Pathogens; Needle-free Jet Injectors for Standardized, Prefilled Cartridge; Safe, Multidose-Vial, Reusable-Fluid-Pathway Jet Injector for Immunization; Operations Research for Expanded Vaccine Selection Algorithm; Develop User-Friendly Neural Network Software for Unix Operating System; EPIDEMIOLOGY PROGRAM OFFICE (EPO): Design and develop an interactive program and training materials for the Guide to Community Preventive Services. The PHS SBIR Contract Solicitation PHS 2000-1, including proposal forms, will be available electronically through the National Institutes of Health's "Small Business Funding Opportunities" home page at http://www.nih.gov/grants/funding/sbir.htm on the World Wide Web. A limited number of hard copies of the PHS SBIR Contract Solicitation will be available from: PHS SBIR/STTR Solicitation Office, 13687 Baltimore Avenue, Laurel, MD 20707-5096, phone: (301) 206-9385, fax: (301) 206-9722, e-mail: a2y@cu.nih.gov. Posted 08/06/99 (W-SN364280). (0218)

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