National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- SPECIALIZED IN VITRO VIROLOGICAL EVALUATIONS OF STRATEGIES TO COMBAT HIV/AIDS SOL RFP NIH-NIAID-DAIDS-00-17 DUE 112699 POC Brenda Brooks, Contract Specialist, (301) 435-2765 The Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement to promote research for the treatment and prevention of HIV disease. This effort encompasses programs in the discovery and development of novel therapeutic strategies for HIV disease and therapeutic-based (drug, biologic, and other) prevention approaches for HIV transmission. The purpose of the planned contract is to evaluate therapies/strategies, alone and in combination, in specialized (cell-based and/or target based) assays. Such therapies/strategies may include: (i) HIV transmission inhibitors (including drug- and immune-based strategies, biologics, and natural products but excluding prophylactic vaccine-based inhibitors); (ii) antiviral agents (drugs and biologics); (iii) immune-based therapies; and, (iv) gene-based therapies. In view of the investigative component of this work, model/assay development will be an important part of this contract. A secondary activity will be the production of standardized reagents (e.g., drug resistant virus variants) generated during the course of these studies. These reagents will be made available through the NIAID Research Reference and Reagent Program (Repository) to the scientific community. It is anticipated that one (1) cost reimbursement, completion type contract will be awarded for a period of seven (7) years, beginning approximately September 1, 2000. RFP NIH-NIAID-DAIDS-00-17 will be available electronically on or about September 3, 1999, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page by using the following electronic address and instructions: NIAID/CMB Home Page (via the WWW): Use http://www.niaid.nih.gov/contract to access the NIAID/CMB Home Page. Once at the NIAID/CMB Home Page, click on the "RFPs" link and then click on "RFP NIH-NIAID-DAIDS-00-17." Please note that the RFP for this acquisition has been revised to include only the Work Statement, Deliverable and Reporting Requirements, Special Requirements and Mandatory Qualification, if any, the Technical Evaluation Criteria, and the Specific RFP Instructions and Provisions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range may be requested to provide additional documentation to the Contracting Officer. Responses to this RFP will be due on or about November 26, 1999. Any responsible Offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of Contact: Brenda Brooks, Contract Specialist. Electronic mail address: bb76n@nih.gov Telephone: (301) 435-2765 FAX: (301) 480-5253 No collect calls will be accepted. Posted 08/24/99 (W-SN371785). (0236)

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