National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

68 -- REAGENTS SOL NCI-RFQ-90213-NR DUE 092019 POC Marsha Gorham, Purchasing Agent & Todd Cole, Contracting Officer The National Institutes of Health, National Cancer Institute (NCI), Division of Basic Sciences (DBS), Laboratory of Cellular Oncology plans to procure HPV (human papiloma virus) virus-like particles from Dyncorp, One Taft Court, Suite 200, Rockville, MD 20850. The Laboratory of Cellular Oncology has an ongoing protocol that involves the cloning of human papiloma virus. Ultimately, this approved protocol may lead to the development of a vaccine that can prevent cervical cancer. In order to carry out the aforementioned protocol, HPV virus-like particles, highly specialized reagents, intended for use in clinical trials, are needed for vaccine trials. DynCorp produced these particles for the earlier phase I HPV vaccine trial within the lab. In continuing the protocol, additional HPV virus-like particles are required. Since the reagents are involved in human clinical trials, good manufacturing practices are essential, and the reagents must meet FDA approval. Additionally, the Laboratory of Cellular Oncologyis in collaboration with NIAID who used the reagents from DynCorp for two years in a similar study. Based on the earlier Phase I portion of the protocol and the collaboration with NIAID, it is necessary to continue with DynCorp's particles in order to avoid introducing new variables into the NCI study and to maintain the comparability of study data between NCI and NIAID. DynCorp is the only organization known to the NCI researcher that can provide FDA approved HPV virus-like particles and that can maintain the comparability and reliability of data within the study. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform this requirement. Capability statements must be received in the contracting office by 3:00 p.m. EST, on September 20, 1999. If you have any questions, please contact Cynthia Brown, Purchasing Agent on (301) 402-4509. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Posted 08/31/99 (W-SN374868). (0243)

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