National Institute of Environmental Health Sciences, Acquisitions Management Branch, 79 T.W. Alexander Drive, Building 4401 Research Commons, P.O. Box 12874, Research Triangle Park, NC 27709

B -- VECTORS PRODUCTION SOL MKQPM90167 DUE 092299 POC Contact Mary Kimble, Contracting Officer (919)541-0388 The National Institute of Environmental Health Sciences is negotiating with Methodist Hospital Foundation in Houston TX, as a sole source under the authority of 41 U.S.C. 253(c)(1) for . The justification for this determination is based upon Texas Medical Center Radiation and Gene Therapy Research Foundation is the sole manufacturer/supplier of AdV.OW34 an E1 enabled replication-competent adenoviral vector expressing the herpes simplex virus-thymidine kinase and Elb 55 kD adenovirus gene to be used in this clinical trial. All responsible sources may respond by submitting a written narrative statement of capability writing 15 days of this notice to Mary Kimble at the above address for consideration by the agency. Response must include the detailed technical information and other technical literature demonstrating the ability to meet these requirements Responses shall also include itemized pricing that is sufficient to make a determination that competition is feasible. If no affirmative responses are received within 15 days of this notice to determine whether a qualified source is more advantageous to the Government, an order will be placed with Airlie Foundation. There is no solicitation package. SIC8733 /Size $5.0M. See Note 22***** Posted 09/02/99 (W-SN375601). (0245)

Loren Data Corp. http://www.ld.com (SYN# 0010 19990907\B-0004.SOL)