National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- MANAGEMENT OF INFORMATION RESOURCES ON THERAPEUTIC AGENTS FOR HIV AND OPPORTUNISTIC INFECTIONS SOL RFP NIH-NIAID-DAIDS-00-31 DUE 012400 POC Barbara A. Shadrick, Senior Contracting Officer, phone 301-496-7288, fax 301-480-5253 WEB: NIAID Contract Management Branch RFPs, http://www.niaid.nih.gov/contract. E-MAIL: Barbara A. Shadrick, bs92y@nih.gov. The Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is soliciting proposals in response to this RFP for the recompetition of contract (NO1-AI-55285) that was originally awarded to Herner & Company and is currently with Cygnus Corporation, Inc. The proposed contract is to be awarded as a 100% Small Business Set-Aside under Standard Industrial Classification (SIC) Code 7375, with a size standard of $18 Million for the management of information resources on therapeutic agents for HIV and opportunistic infections. DAIDS supports research to identify therapeutic agents for the prevention and treatment of infections with the human immunodeficiency virus (HIV) and opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS) including Mycobacterium tuberculosis. Lead compounds are identified through individual research grants as well as DAIDS-sponsored programs such as the Integrated Preclinical Program for Novel HIV Therapies, and the National Cooperative Drug Discovery Groups for AIDS-associated Opportunistic Infections (OIs). Researchers in these and other DAIDS-sponsored pre-clinical programs are actively engaged in investigating the basic biology of the targeted pathogens, identifying novel therapeutic approaches to treat diseases caused by these infectious agents, and testing therapeutic strategies in animal models. Data bases containing chemical structures and biological data have been established by the Division of AIDS (DAIDS) to track development of chemotherapies of HIV and OIs and to serve as a knowledge base for the NIAID and scientific community. The current databases are the most up-to-date information source available on current research on experimental therapies for HIV and opportunistic infections. A high level of professional and administrative capabilities must be exhibited by the offerors in order to: provide scientific expertise (chemistry, virology, immunology, microbiology) for literature surveillance, data retrieval and quality control, and to recommend enhancements which allow for changes and improvements in the transfer and/or retrieval of data. The databases provide support for the acquisition of new chemicals for biological evaluation in contracts sponsored by DAIDS. Currently, DIADS maintains six databases which contain chemical and biological information on: 1) anti-HIV therapeutic agents (15,000 chemical structures); 2) agents tested for activity against opportunistic pathogens (5,000 compounds); 3) agents tested for activity against M. tuberculosis (30,000 structures); 4) HIV chemical/biological database WEB site that contains 500 HIV compounds; 5) microbecidal database (1850 compounds); and 6) literature citations (8,500) on relevant AIDS therapies. The anti-HIV and anti-OI databases currently are managed using ISIS-TM/Base and ISIS/Host (AIX) software (MDL Information Systems, Inc., San Leandro, CA), and ORACLE for data tables, ISIS/HOST and ORACLE version 8.0.5 hosted on Silicon Graphics Origin 200 system; the literature citations database is managed using PROCITE-TM software version 4.1 (Personal Bibliographic Software, Inc., Ann Arbor, MI). It is anticipated that one cost reimbursement, completion type contract will be awarded for a period of seven years, beginning on/before September 21, 2000. The amount of effort for all seven years is estimated at 39.2 FTEs. RFP-NIH-NIAID-DAIDS-00-31 will be available electronically on or about October 20, 1999, and may be accessed through the NIAID Contract Management Branch (CMB) Home Page by using the following electronic address and instructions: NIAID/CMB Home Page (via the World Wide Web): Access by using http://www.niaid.nih.gov/contract and select the "RFPs" link and then select "RFP-NIH-NIAID-DAIDS-00-31." All information required for the submission of an offer will be contained in the electronic RFP package. Any responsible offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. See Numbered Note 1. No collect calls will be accepted. Posted 10/04/99 (W-SN388099). (0277)

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