U.S. Department Of Energy, Document Control Specialist, Washington, DC 20585

B -- NUCLEAR MEDICINE RESEARCH USING ISOTOPES SOL DE-PS01-00NE22740 DUE 012800 POC John Pantaelo, Program Manager, 301-603-2525; Richard G. Lewis, Contracting Officer, 202-426-0066 NOTICE OF PROGRAM INTEREST (NOPI) TO THE PUBLIC The Office of Isotope Programs, Office of Nuclear Energy (NE) solicits responses for research programs for new and innovative uses of isotopes, including alpha emitting isotopes in the diagnosis and therapy of cancer, HIV and other infectious diseases or other innovative medical applications. The diagnosis and therapy of many diseases with the use of isotopes will be the subject of a high risk/high impact research program the Department calls the Advanced Nuclear Medicine Initiative (ANMI). The Department wishes to encourage research in these areas by providing resources for the required research. This program is not intended to support human clinical trials. Researchers with innovative ideas in the use of isotopes for diagnosis and therapy of many diseases have had difficulty obtaining funding for areas of research that are not closely tied to specific isotopes, means of delivery and disease. The purpose of the ANMI is to support broad-based research on new uses of isotopes, including alpha emitters for the diagnosis and therapy of life threatening disease or other innovative medical applications. The Department is looking for applications in these areas with the view toward providing funding or the required isotopes as part of a research program. One means of obtaining complete details, instructions on how to apply, opening and closing dates and the forms may be obtained from the DOE NE home page on the internet at: http://www.ne.doe.gov The second means of obtaining the formal solicitation document will be disseminated electronically as solicitation number DE-PS01-00NE22740 through the Department's Industry Interactive Procurement System (IIPS) Homepage located at http://doe-iips.pr.doe.gov. Effective October 1st, 1999, the IIPS system became the primary way for the Office of Headquarters Procurement Services to conduct competitive acquisitions and financial assistance transactions. IIPS provides the medium for disseminating solicitations, receiving financial assistance applications and proposals, evaluating, and awarding various instruments in a paperless environment. To get more information about IIPS and to register your organization, go to hhp://doe-iips.pr.doe.gov. Follow the link on the IIPS home page to the Secure Services Page. Registration is a prerequisite to the submission of an application, and applicants are encouraged to register as soon as possible. When registering, all applicants should use the same North American Industry Classification System number 325412. A help document, which describes how IIPS works, can be found at the bottom of the Secure Services Page. The DOE points of contact are John Pantaleo, Program Manager at 301-903-2525 and Richard G. Lewis, Contracting Officer at 202-426-0066. Posted 12/09/99 (W-SN407397). (0343)

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