National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- ESTABLISHMENT OF A GENETIC SYSTEM IN CANDIDA ALBICANS SOL SS-DMID-00-33 DUE 021800 POC Mr. Paul D. McFarlane, Senior Contracting Officer, 301-496-0349 The National Institute of Allergy and Infectious Diseases intends to negotiate for a three-year contract with the University of Minnesota. The nature of the work involves completing the creation of the physical map, closure of gaps, location of centromeres, and maintenance of a reference repository of phosmid clones containing the contigs for the genome of the opportunistic fungal pathogen, Candida albicans. University of Minnesota is uniquely qualified to perform this work, and the resulting information on the genome organization of C. albicans will enable the scientific community to study the basic biology and virulence of C. albicans, which it's hoped, will lead to better means of diagnosis, prevention and treatment of the multiple clinical presentations of candidiasis. The public health importance of the proposed work as well as inherent duplication of cost to the government and unacceptable delays in initiating and completing the project makes competition unfeasible. Therefore, the government intends to proceed with a sole source award under the authority of 41 U.S.C. 253(c)(1) as set forth in FAR 6.302-1. See Numbered Note 22. Posted 01/04/00 (W-SN413038). (0004)

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