National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch, 6701 Rockledge Drive, Room 6100, MSC 7902, Bethesda, MD 20892

B -- ACCESS TO THE CAMBRIDGE STRUCTURAL DATABASE SOL NHLBI-RR-P-00-551 POC Christopher Belt, Phone: 301-435-0366, Fax: 301-480-3345 NIH intends to procure on a sole source basis to the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ United Kingdom for access to the Cambridge Structural Database for the U.S. Government and the U.S. Academic Biomedical Research Community. The period of performance shall be for one twelve (12) month period, with options to renew for four (4) additional twelve (12) month periods. It is believed that the Cambridge Crystallographic Data Centre is the sole source for this requirement under the authority of FAR 6.302-1 because of the following: The Cambridge Structural Database (CSD) is a numeric database containing: (1) evaluated crystallographic data together with atomic co-ordinates and estimated standard errors for about 210,000 organic and organometallic; crystal structures (2) chemical connectivity tables relating to these molecules, and (3) bibliographic data fields showing the reference sources for the above data. It also includes an extensive library of information derivedfrom the extended crystal structures corresponding to the primary data. This database is used by researchers around the world who study molecular structure and the relationship between molecular structure and biological activity. The responsibility for and management of collecting, validating, and distributing, the data contained in this database has been assigned by the International Union of Crystallography to one international collection centre: the Cambridge Crystallographic Data Centre, Cambridge, United Kingdom. New data is added to the database at the rate of approximately 20,000 compounds per year. The Cambridge Crystrallographic Data Centre controls the collection, validation, and distribution of crystallographic data for the entire scientific community. The database represents the work of a large scientific team over the past 29 years. It is believed that this database cannot be obtained from any other source nationally or internationally, and is the only available file of X-ray crystallography coordinates for biologically active compounds of low molecular weight. These data files are unique and universally used in research for molecular modeling, drug design, to reproduce models of molecules and make comparisons of molecular structure, as well as fundamental research on molecular structure, materials design and crystal engineering. Interested parties may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive proposals. However, all proposals received within 15 days after publication of this synopsis will be considered by the Government. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement. Posted 01/06/00 (W-SN413577). (0006)

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