National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- HIV/SIV DATABASE AND ANALYSIS UNIT SOL RFP-NIH-NIAID-DAIDS-01-05 DUE 050100 POC Grace Bruce, Contract Specialist, (301) 496-0195 The Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), NIH, has a requirement for a specialized database that will serve as an international research resource for the compilation, analysis and dissemination of genetic sequence and associated data for HIV-1 and related lentiviruses. The proposed contract will continue the work of the current HIV Database and Analysis Unit located at the Los Alamos National Laboratory, funded by Interagency Agreement Y1-AI-7043, in addition to creation and maintenance of an additional database containing information on SIV/SHIV genetic sequences, immunological epitopes, and an up-to-date summary of all vaccine studies conducted in SIV/SHIV/HIV non-human primate models. The summary of non-human primate vaccine studies is currently carried out under contract N01-AI-45205. The contractor will receive, compile, store and manage genetic and associated biological and immunological data for HIV-1 and related lentviruses and for cellular proteins of interest in AIDS pathogenesis studies. Genetic sequence data will be obtained as GenBank entries, and this information enhanced by the addition of pertinent data extracted from publications. There are over 29,000 HIV and HIV-related sequences in the current database. In-depth analysis will be required of all genetic sequence data. HIV immunology data is obtained from published reports and compiled in a separate database. This database will contain epitope alignments, maps and reference information for cytotoxic and helper T-cell epitopes and antibody binding sites in HIV-1 immunologically reactive sites. Non-human primate AIDS vaccine data is obtained from literature searches, meeting presentations and personal communication. All three databases will be mounted as relational databases accessible via the Internet and designed for ease of search by the user community. The contractor will also be required to design or otherwise obtain state-of-the-art analysis packages that can be provided to the user community via the Internet. As a reference, the current sites can be accessed at the following Internet addresses: http://hiv-web.lanl.gov/ and http://hiv-web.lanl.gov/immunology/index.html. In addition, the contractor will be required to publish three annual publications containing up-to-date information on genetic sequence and immunology of HIV-1 and related lentiviruses, and to deliver these compendia to all interested parties (current mailing lists are 1,500 and 600 for the genetic sequence and immunology compendia, respectively). This research requires that the HIV/SIV Database and Analysis Unit staff have extensive experience in a number of areas related to genetic sequence data compilation, management and analysis in general and as it applies to AIDS research, and in Internet web site design and management. The research will also require a staff with experience in AIDS-related molecular genetics and molecular immunology. The purpose of this contract is to support the NIAID in its mission to stimulateresearch towards discovery and testing of prototype vaccines and prevention interventions for the acquired immunodeficiency syndrome (AIDS). This is an announcement for a Request for Proposals (RFP). It is anticipated that one (1) completion type cost-reimbursement contract for a seven-year period of performance will be awarded as a result of this solicitation. RFP NIH-NIAID-DAIDS-01-05 will be available electronically on or about January 31, 2000, and may be accessed through the NIAID Contract Management (CMB) Home Page (via the World Wide Web): Access by using http://www.niaid.nih.gov/contract and select the "RFP" link. Please note that the RFP for this procurement has been revised to include only the Statement of Work, Reporting Requirements, the Technical Evaluation Criteria, and proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Responses to this RFP will be due no later than 4:30 p.m. (E.S.T.) on May 1, 2000. This advertisement does not commit the Government to award a contract. Point of Contact: Ms. Grace Bruce, Contract Specialist, Contract Management Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700-B Rockledge Drive, Bethesda, Maryland 20892-7628. Electronic mail address: gbruce@niaid.nih.gov. Phone: (301)496-0195. Fax: (301)402-0976. No collect calls will be accepted. All proposals from responsible sources will be considered by the NIAID. Posted 01/14/00 (W-SN416111). (0014)

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