National Institutes of Health, National Institute of Allergy and Infectious Diseases, Contract Management Branch, Room 2230, 6700-B Rockledge Drive, MSC 7612, Bethesda, MD 20892-7612

A -- SIMIAN VACCINE EVALUATION UNITS (SVEUS) SOL NIH-NIAID-DAIDS-01-04 DUE 050500 POC Ms. Grace Bruce, Contract Specialist, 301-496-0195 The National Institute of Allergy and Infectious Diseases (NIAID), NIH has a requirement to establish Simian Vaccine Evaluation Units (SVEUs) preclinical evaluation of the immunogenicity and efficacy of promising SIV and HIV candidate vaccines in non-human primates. Studies are conducted at the initiation of the NIAID, and vaccines to be evaluated are selected by NIAID. The SVEUs conduct preliminary studies on new vaccines, conduct larger-scale studies on vaccines that have already demonstrated promise, evaluate the immunogenicity and safety of candidate HIV vaccines in anticipation of Phase I human clinical trials, and conduct comparative studies on vaccines and/or adjuvants from multiple sources. The SVEUs may also conduct studies with passively administered vaccines. The SVEUs are expected to provide non-human primates for the studies, immunize animals with candidate vaccines, conduct initial assessments of immune responses, challenge the non-human primates with infectious virus, and determine whether or not the animals become infected. The SVEUs also conduct in vivo titrations of virus challenge stocks and may conduct microbicide studies to evaluate the ability of topically administered microbicides and other antiviral substances to block infection of non-human primates with virus administered vaginally or by other mucosal routes. The proposed contracts will continue the work of the current SVEUs. It is anticipated that four to seven (4-7) completion type contracts will be awarded as a result of this solicitation. RFP-NIH-NIAID-DAIDS-01-04 will be available electronically on or about February 21, 2000 and may be accessed through the NIAID Contract Management Branch (CMB) Home Page (via the World Wide Web): Access by using http://www.niaid.nih.gov/contract and select the "RFP" link. Please note that the RFP for this acquisition has been revised to include only the Work Statement, Reporting Requirements and Deliverables, Evaluation Factors for Award, Applicable RFP References and Specific RFP Instructions. All information required for the submission of an offer will be contained in the electronic RFP Package. Responses to this RFP will be due no later than 4:30 p.m. (E.S.T.) on May 5, 2000. Point of Contact: Grace Bruce, Contract Specialist, Contract Management Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700-B Rockledge Drive, Bethesda, Maryland 20892-7612. Electronic mail address: gb15w@nih.gov. Phone (301) 496-0195. Fax: (301) 402-0972. No collect calls will be considered by the NIAID. All proposals from responsible sources will be considered by the NIAID. This advertisement does not commit the Government to award a contract. Posted 02/03/00 (W-SN421389). (0034)

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