Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550

A -- LAWRENCE LIVERMORE NATIONAL LABORATORY SEEKS PARTNERSHIPS WITH INDUSTRY TO COMMERCIALIZE TECHNOLOGY FOR PRODUCING CHROMOSOME-REGION SPECIFIC GENE EXPRESSION LIBRARIES SOL CBD00-014 DUE 040700 POC Industrial Partnerships and Commercialization Office (925) 423-3139 Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy (DOE), is seeking one or more industrial partners to commercialize technology for producing cDNA libraries for various species, tissues, chromosome regions, or disease states. LLNL has developed a process to make gene expression libraries from specific regions of chromosomes for any species using any tissue, whether normal or diseased. The technology may be used to determine the involvement of either known or novel, unknown genes in various diseases. It may also be used to identify genes from any genomic region, which are expressed in response to changes in physiologic state, including pharmacological or toxicological exposure. This technology can also be used to map genes to chromosomes or chromosome regions in species with genomes that are not well characterized. Chromosome-region specific libraries may be useful for both clinical and research applications. Note: This is not a procurement. Companies interested in commercializing LLNL's gene expression technology should provide a written statement of interest that must include a description of corporate capability and experience relevant to commercializing the technology and a detailed commercialization plan. The statement of interest should be sent to: Lawrence Livermore National Laboratory Industrial Partnerships and Commercialization Office P. O. Box 808, L-795 Livermore, CA 94551 Attention: CBD00-014. Please provide your written statement within sixty (60) days from the date this announcement is printed to ensure consideration of your interest in this technology. Posted 02/07/00 (W-SN422591). (0038)

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