National Institutes of Environmental Health Sciences, Research Contracts Branch, DERT, P.O. Box 12874, Building 4401, Research Commons, 79 T.W. Alexander Drive, Research Triangle Park, NC 27709

A -- CHEMISTRY SUPPORT SERVICES FOR THE ENVIRONMENTAL TOXICOLOGY PROGRAM!! SOL NIH-ES-00-24!! DUE 041200 POC Contract Specialist, Saundra J. Walsh, 919-541-0419 or e-mail at WEB: NONE, NONE. E-MAIL: NONE, NONE. The National Institute of Environmental Health Sciences is soliciting proposals for the Environmental Toxicology Program (ETP) and the Division of Intramural Research (DIR) chemistry support services to ensure that animal species under study are exposed to the prescribed chemicals at the specified dose concentrations. Chemistry support services include chemical characterization, dose preparation, dose concentration verification, and internal dose determination. Up to three contract awards will be made with only one award permitted per Contractor. These contracts shall provide the basic chemistry services for the Two-Year Bioassay, Short-Term Toxicology, Developmental Toxicology, Reproductive, Developmental and General Toxicology Screen, Reproductive Assessment by Continuous Breeding, Immunology, and Neurotoxicology Programs and In-House research efforts. Each contract shall include three options that may be exercised on an annual basis. Option 1 will provide for bulk chemical procurement support for the Genetic Toxicology Program and other non-AIDS programs. Option 2 will provide chemistry support for the AIDS program. Option 3 will provide additional broad chemical support for all non AIDS programs. It is anticipated that one, two, or all three options may be exercised during a given year. It is further anticipated that exercising an option or options will result in an increase in the number and types of tasks to be performed with no increase in the period of performance of the contract. Each contract, Base (B) and Options 2 (O2) and 3 (O3) shall include the conduct of twenty-five tasks to be conducted in the following quantities: (1) Bulk Chemical Procurement (B = 43 chemicals, O2 = 2 tasks, and O3 = 13 tasks per year), (2) Bulk Chemical Handling (B = 12, O2 =2, and O3 = 5 tasks per year), (3) Preliminary Chemical Studies (B = 4, O2 = 0, and O3 = 4 tasks per year), (4) Bulk Chemical Comprehensive Analysis (B = 3, O2 = 0, and O3 = 1 chemical(s) per year), (5) Bulk Chemical Limited Analysis (B=16, O2 = 3, and O3 = 6 chemicals per year), (6) Bulk Chemical Inhalation Analysis (B = 1, O2 = 0, and O3 = 1 chemical per year), (7) Bulk Chemical Reanalysis using previously developed methods (B = 6, O2 = 1, and O3 = 14 tasks per year), (8) Bulk Chemical Protocols (B = 15, O2 = 3, and O3 = 6 tasks per year), (9) Dose Formulation Developmental Studies (B = 16, O2 = 3, and O3 = 6 chemicals mixed in feed or in "other" vehicles per year), (10) Formulation Preparation (B = 5, O2 = 2, and O3 = 2 chemicals per year), (11) Formulation Preparation Analysis (B = 13, O2 = 2, and O3 = 6 sets per year), (12) Formulation Analysis (B = 21, O2 = 4, and O3 = 14 sets /year), (13) Referee Analysis (B = 1, O2 = 1, and O3 = 1 tasks /year), (14) Dose Vehicle Analysis (B = 9, O2 = 2, and O3= 3 Analyses/tasks per year), (15) Chemical Storage (B = 12, O2 = 1, and O3 = 6 tasks /year), (16) Shipments (B = 77, O2 = 4, and O3 = 31 tasks per year), (17) Hazardous Chemical Disposal (B = 1, O2 = 1, and O3 = 1 task per year), (18) Specials (B = 30, O2 = 4, and O3 = 5 tasks /year), (19) Biological Sample Methods Development (B = 11, O2 = 2, and O3 = 2 tasks per year), (20)Toxicokinetic Study (B = 1, O2 = 1, and O3 = 1 task /year), (21) Biological Sample Analysis (B = 15, O2 = 3, and O3 = 5 tasks per year), (22) Preliminary Toxicokinetic Study (B = 2, O2 = 2, and O3 = 2 tasks /year), (23) Preliminary Biological Sample Analysis (B = 2, O2 = 2, and O3 = 2 Tasks per year), (24) Extended Stability Study (B = 4, O2 = 2, and O3 = 2 tasks per year) and (25)Partition Coefficient Determination (B = 1, O2 = 1, and O3 =1 Task per year). Option 1 shall consist of Task 1, Bulk Chemical Procurement. The anticipated effective date for the subsequent awards is September 30, 2000. The performance period for each contract is expected to be five (5) years, with an additional 120 days for submission of the final report and phase-in/phase-out activities. For estimating purposes the Government anticipates an approximate level-of-effort of 40,326 direct labor hours per year for each base contract, 522 direct labor hours per year for each contract to perform Option 1, 10,754 per year for each contract to perform Option 2 and 17,804 per year for each contract to perform Option 3 tasks. The Government anticipates the participation of a senior research professional (i.e. Project Leader, Principal Investigator), Research Professionals (i.e. Group Leader, Project Engineer, or Task Leader), professionals (i.e. Analyst, Engineer, or Scientist), technical staff and support staff (i.e. secretary, data coordinator) The expected release date of the RFP is March 1, 2000 with proposals due April 12, 2000. Interested organizations should request either a streamlined or full RFP package. If no selection is made, a streamlined version of the RFP will be provided, which includes only the Statement of Work, deliverable and reporting requirements, special requirements and mandatory qualifications, if any, and technical evaluation criteria. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP in writing or by telephone (919) 542-0419 or by FAX request (919) 541-2712. On the release date, a copy of the streamlined and full version of the solicitation will be available, on the Internet at: http://www.niehs.nih.gov/omcpmb/external/. Those individuals who wish to access the on-line version should follow the instructions provided in the on-line solicitation package. After examination of these documents, any organization interested in responding to this RFP must request the entire RFP in writing or by telephone (919) 541-0419 or by FAX request (919) 541-2712. This requirement is unrestricted. SIC Code 8731.***** Posted 02/08/00 (W-SN423361). (0039)

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