National Cancer Institute, Research Contracts Branch, ESS, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

B -- FAMILIAL CASE-CONTROL STUDY OF LYMPHOPROLIFERATIVE MALIGNANCIES AND AUTO-IMMUNE DISORDERS: A POPULATION BASED RECORD LINKAGE SOL N02-CP-01024-38 POC Kim L. Hall, Contract Specialist, (301) 435-3781 E-MAIL: Kim Hall, kh175r@nih.gov. The Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI) is seeking a contractor who will provide managerial and computer processing support in order to carry out record-linkage studies to quantify the familial aggregation of lymphoproliferative malignancies and test the hypothesis that autoimmune diseases also aggregate in families of cases with lymphoproliferative malignancies. The objectives of this record-linkage project are: 1) create a database comprised of all cases selected from a population-based cancer registry, having a diagnosis of one of four lymphoproliferative malignancies (Non-Hodgkin's Lymphoma, Hodgkin's Disease, Chronic Lymphocytic Leukemia, and Multiple Myeloma) and all parents, offspring and siblings of cases that have been linked to them by use of a population-based family registry (defined as a registry that identifies parents of all individuals born or alive at a certain date, siblings being identifiable through the parental identifiers); 2) select a control group (random sample of individuals free of any leukemia or lymphoma) matched to the cases from the same population-based family registry and all parents, offspring, and siblings of controls that have been linked to them by use of a population-based family registry; 3) obtain cancer diagnosis on cases, controls, and all relatives selected above; and 4) obtain all hospital diagnoses of autoimmune disease from a hospital register on cases, controls, and all relatives. It is anticipated that an incrementally funded, cost-reimbursement, completion type contract will be awarded for a two-year period of performance. The anticipated date of the Request for Proposal (RFP) is 15 days from the date of this notice, with responses due 30 days thereafter. All responsible sources meeting these criteria are encouraged to submit an offer and will be considered by the National Cancer Institute. No collect calls will be accepted. Posted 02/10/00 (W-SN424006). (0041)

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