DHHS/National Institute on Alcohol Abuse and Alcoholism, Contracts Management Branch, Wilco Building, Suite 504, 6000 Executive Boulevard, MSC 7003, Bethesda, Maryland 20892-7003

A -- PSYCHOBIOLOGY OF FREE-RANGING RHESUS MONKEYS SOL AA-00-03 POC Edward J. Kostolansky, Contract Specialist, 301-443-1191 WEB: NIAAA Home Page, http://www.niaaa.nih.gov. E-MAIL: Sandra Reichard, sreichar@willco.niaaa.nih.gov. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to negotiate with LABS of Virginia, Incorporated, for a three year contract to study genetic and biochemical determinants of excessive and impulsive aggression in free-ranging juvenile and adolescent and young adult male and female nonhuman primates. The proposed procurement will continue identification and active maintenance of a homogenous population of aggressive juvenile rhesus monkeys, to be freely selected by the Laboratory of Clinical Studies -- Primate Section, NIAAA. Biological samples will be collected consisting of repeated CSF samples to assay for neurotransmitter activity, blood samples to assay for hormone concentrations, skin biopsy samples to harvest for DNA to perform molecular genetic analyses, behavioral samples consisting of frequency and duration of social interactions, aggression, risk taking, social dominance, troop residence, and automated computerized collection of individual activity rates and sleep patterns in a sample of free-ranging juvenile, adolescent, and young adult rhesus macaques. Authority: 41 U.S.C. (c)(1), as set forth in FAR 6.302-1. LABS of Virginia is the only known source with a sufficient population to perform this study. Any inquiries must be submitted to NIAAA in writing. See Numbered Notes 22 and 26. Posted 02/11/00 (W-SN424644). (0042)

Loren Data Corp. http://www.ld.com (SYN# 0001 20000215\A-0001.SOL)