National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

99 -- ROTATING GENERATOR SOL RFQ-NCI-00052-NQ DUE 030600 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Todd Cole, Contracting Officer The National Institutes of Health, National Cancer Institute (NCI), Laboratory of Cell Biology, intends to procure on a sole-source basis with Molecular Structure Corporation, 3200 Research Forest Drive, The Woodlands, TX 77381 under the authority of 41.U.S.C. 253(c)(1), FAR 6.3202-1 an RIGAKU RU-H3R Rotating Anode X-ray Generator with accessories. The Laboratory of Cell Biology studies structure and function of macromolecular assemblies, especially those related to cancer development, treatment, and prevention, primarily using X-ray crystallographic methodology. The generator also requires an X-ray diffraction facility for examining and collecting data on protein crystals. X-ray crystallography is the most dominant method in elucidating macromolecular structures and plays an essential role in understanding biological function of proteins at atomic level. The Rigaku RU-H3R rotating anode X-ray generator is the only commercially available design which can deliver suitable X-ray beam sufficiently strong (16- 18kW) for modern macromolecular crystallography as an in-house X-ray source while remains simple for routine maintenance. NCI has determined that Molecular Structure Corporation is the only source that can provide the exact product meeting its requirement. In-house X-ray generators use tungsten filament for X-ray generation; most filaments have a life time between 2500 to 3000 hours, and change of filament is part of routine maintenance for every design of X-ray generator. Because the direction of X-ray is critically dependent on the position of the filament, it is therefore necessary desirable to have the prealigned filament offered by the Rigaku X-ray generator, which would basically ensure the same direction of X-ray every time the filament is replaced. The RIGAKU RUH3RHB generator is the only one known to the NCI Researcher that has the required features. This is not a request for competitive quotation, however, if any interested party believes it can meet the above requirement, they may submit a statement of capabilities. Information furnished must be in writing and must contain sufficient detail, to allow NCI to determine if the party can meet the requirement. Capability statements must be received in the Contracts Office by 2:00 P.M. EST on March 6, 2000. If you have any questions, please contact Cynthia Brown, Purchasing Agent on (301) 402-4509. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Please reference RFQ-NCI-00052. Posted 02/16/00 (W-SN425840). (0047)

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