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COMMERCE BUSINESS DAILY ISSUE OF FEBRUARY 18,2000 PSA#2540Director, USAMRAA, 820 Chandler St, Fort Detrick, MD 21702-5014 A -- GULF WAR ILLNESSES RESEARCH: TOXICITY OF MILITARILY-RELEVANT
HEAVY METALS SOL CBD-GWI-0202 POC Craig D. Lebo, Contracting Officer,
301-619-2036 The U.S. Army Medical Research and Materiel Command is
soliciting proposals for studies on biological effects of heavy metals
currently used or contemplated for use in armor and as armor
penetrators. These include tungsten and tungsten alloys, depleted
uranium, depleted uranium and titanium alloys, and oxidation products
of these metals and their alloys. Inclusion of positive (e.g. lead) and
negative (e.g. tantalum) controls should be considered in study
designs. Outcomes of special interest include identification of
mechanisms of injury to pulmonary, hepatic, renal, and nervous systems
from particulate and solubilized forms; and localized soft tissue
responses produced by embedded fragments (distinguishing foreign body,
radiation, toxicological and acute phase responses). Exposures should
be based on realistic scenarios, should consider current
pharmacokinetic and pharmacodynamic knowledge of the metal or alloy
under study, and could include epidemiological studies based on
exposure models. Proposals must provide a clear justification and
military relevance. Submission of preliminary data is encouraged.
Collaborations with DoD medical researchers are encouraged. Awards are
expected to average $200K per year for up to four years of support. A
total of approximately $5M will be made available for studies in this
topic. Proposals should be submitted according to general instructions
contained in the Broad Agency Announcement 99-1 (see
http://www-usamraa.army.mil). Preproposals are not required; letters of
intent (LOI) containing a proposed title, brief description of project
scope (<150 words), and investigator and institution identification
are due by 14 June 2000. These LOI will be used to plan the review
process. Do NOT expect a response to your LOI. Full proposals are due
no later than 4 p.m., EST, 26 July 2000. Send letters of intent and
proposals to: Commander, U.S. Army Medical Research Acquisition
Activity, ATTN: GWIRP2000, 820 Chandler Street, Fort Detrick, MD
21702-5014. Posted 02/16/00 (W-SN425880). (0047) Loren Data Corp. http://www.ld.com (SYN# 0017 20000218\A-0017.SOL)
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