National Cancer Institute, Research Contracts Branch, ESS, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

B -- GENETIC EPIDEMIOLOGY OF LUNG CANCER AND SMOKING SOL N02-CP-01006-50 DUE 042000 POC Karen L. McFarlane, Contracting Officer Representative, (301) 435-3782 WEB: Research Contracts and Acquisition Branch, http://amb.nci.nih.gov/. E-MAIL: Karen L. McFarlane, km63k@nih.gov. ELECTRONIC RFP ANNOUNCEMENT, POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. The Genetic Epidemiology Branch (GEB) of the National Cancer Institute (NCI) is seeking out a contractor to provide support for an interdisciplinary case-control/sib-pair study of lung cancer designed to explore the genetic determinants of both lung cancer and of smoking. Approximately 4,000 subjects (2,000 cases and 2,000 controls), in addition to siblings will be identified and questionnaires and biospecimens collected in a relatively short period of time (1.5 -- 2 years). Although the scientific design and oversight of the activities are the responsibility of the Genetic Epidemiology Branch (GEB) Professional staff, the major activities of the contract include providing support in a variety of areas including: 1) general aspects of the case control study (study initiation, study liaison, study approvals, etc.); 2) selection and recruitment of study participants (case ascertainment, control ascertainment, sibling ascertainment); 3) collection of biospecimens from study participants; 4) data collection; 5) data management; 6) establishment of a laboratory to process and store biospecimens collected from study paricipants; and 7) transportation of biospecimens, data, and materials collected from study participants. The anticipated solicitation issue date is approximately 21 days after publication of this notice, and proposals will be due approximately 30 days after the issue date. The RFP may be accessed via the NCI Research Contracts Acquisition Branch (RCAB) website: http://amb.nci.nih.gov/ under "Current Requests for Proposals". All responsible sources may submit a proposal which shall be considered by the NCI.. Award of this project is anticipated by August 31, 2000. No collect calls will be accepted. (0027) Posted 02/28/00 (W-SN429093). (0059)

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