National Cancer Institute, Research Contracts Branch, ESS, Executive Plaza South, Rm. 620, 6120 Executive Blvd., MSC 7224, Bethesda, MD 20892-7224

A -- CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORTS SOL N01-CP-01012-21 POC Shawnee J. Shaw, Contract Specialist, (301) 435-3778 The Division of Cancer Epidemiology and Genetics (DCEG), Epidemiology and Biostatistics Program (EBP), of the National Cancer Institute (NCI) is seeking collaborative investigators to continue follow-up of established DES cohorts to measure the incidence and mortality of cancer, especially cancers of the breast and reproductive system. The secondary objectives include assessment of other health effects suggested as being related to DES exposure, monitoring for as yet unanticipated health risks, and utilization of the cohorts as a platform to launch more intensive and focused case-control studies of specific DES-related conditions. Each collaborating investigator shall be required to furnish all the necessary services, qualified personnel, material, equipment, and facilities, not otherwise provided by the government, as needed to continue follow-up of surviving members of a cohort of at least 500 mothers, dughters, sons, and grandchildren exposed to diethylstilbestrol (DES). Disease outcomes will be ascertained by means of questionnaires, medical record reveiw, and tissue sampling as appropriate. The contracts to be awarded will be cost-reimbursement, completion types. All responsible sources meeting these criteria are encouraged to submit an offer and will be considered by the National Cancer Institute. It is anticipated that the solicitation package will be available on/about March 17, 1999, with proposals due 45 calendar days after the issue date of the RFP. Award is anticipated by September 30, 2000. No collect calls will be accepted. Posted 02/29/00 (W-SN429445). (0060)

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