Centers For Disease Control And Prevention (CDC), Procurement & Grants Office, 2920 Brandywine Road, Atlanta, Georgia 30341-4146

B -- HIV-1 DRUG RESISTANCE CHARACTERIZATION; GENOTYPIC AND PHENOTYPIC ANALYSIS OF HIV-1 STRAINS SOL 2000-N-00054 DUE 042700 POC Dale DeFilipps, Contract Specialist, Section 2, (770) 488-2637, Mailstop K-69 The Centers for Disease Control and Prevention (CDC) contemplates awarding a contract for laboratory studies on antiretroviral drug resistance for selected HIV-1 strains from throughout the United States. Two methods shall be used by the contractor. The first, genotypic characterization, shall be used on all specimens and involves direct genetic sequencing of the polymerase-protease area of the HIV-1 virus. The second, phenotypic characterization, shall be used on a subset of specimens, based on genotypic findings, and is the biological determination, through recombinant and cellular methods, of antiretroviral drug susceptibility. The contractor shall possess the following minimum qualifications to perform these tasks: The contractor must be able to perform sequencing for genotypic analysis and conduct recombinant phenotypic analysis using an established recombinant method or subcontract to have the phenotypic analysis performed. The contractor (or its subcontractor) shall have experience in providing specialized information through phenotypic drug susceptibility tests (and these can be applied to many viruses, such as HIV, HBV, HCV, and herpesvirus). Also, the contractor must be active in the HIV antiretroviral resistance publication arena. The anticipated performance period is fifteen months or when 800 specimens have been genotyped and, based on the genotypic results, when approximately 100 of those specimens have been phenotyped, whichever comes first. The solicitation will be issued as a full and open competition procurement. The Standard Industrial Classification is 8733 which has a size standard of $5 million. The date specified for receipt of offers will be approximately 30 days after the RFP issue date. Requests for the RFP must specify the RFP No. 2000-N-00054. Telephone requests will not be accepted. Posted 03/06/00 (W-SN431482). (0066)

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