Bid Office, SPAWARSYSCEN, Code D21B, 53570 Silvergate Avenue, Bldg. A33, Room 0061, San Diego, CA 92152-5112

A -- ILLICIT DRUG DEMAND REDUCTION AND SUPPORT SOL N66001-00-X-6004 DUE 033101 POC Maureen Battern, (619) 553-4489 WEB: click here and then open business opportunities under, e-commerce.spawar.navy.mil/. E-MAIL: click here to contact the contract specialist, battern@spawar.navy.mil. The Space and Naval Warfare Systems Center, San Diego, (SPAWARSYSCEN, San Diego) in support of the Office of National Drug Control Policy (ONDCP) Counterdrug Technology Assessment Center (CTAC) is soliciting white papers and proposals for innovative research and development projects related to the reduction of the demand for illicit drugs and other substances of abuse. The intent of this BAA is to identify research and scientific approaches and technologies that enhance our National capabilities to meet the strategic Demand Reduction goals of ONDCP. These initiatives will complement those of the National Institute on Drug Abuse (NIDA), Department of Health & Human Services in prevention and treatment research, and the development of state-of-the-art medical research instrumentation and equipment. AREAS OF INTEREST: This BAA focuses on initiatives associated with Demand Reduction and Support projects that would contribute to sound science and the development of technological solutions and applications for state-of-the-art medical research systems, methods, and protocols, supporting drug abuse prevention and treatment research, enhancement of our understanding of the effects of drugs on the body, techniques for assessing and monitoring drug addiction and abuse severity, and techniques for treatment/client matching. SPAWARSYSCEN, San Diego, in collaboration with ONDCP and NIDA are committed to improving the investigative tools available for research scientists and engineers to explore and understand the underlying causes of substance abuse, dependence, and addiction. Sophisticated imaging and chemical assay technologies and related studies are needed to effectively pursue the challenge of reducing the demand for illicit drugs through applied psychology, pharmacology, neurology, biology, and clinical treatments. Prime areas of interest are: -Magnetic resonance spectroscopy, perfusion, structural and functional magnetic resonance imaging, single photon emission computer tomography, positron emission tomography, computed axial tomography, electro-encephalographic-based evoked potential, and chemical assay systems to study the drug or craving-induced metabolic and chemical processes, map brain reward circuitry, assess metrics associated with behavior, measure blood volume and flow associated with drug metabolism, analyze interactions with potential therapeutic medicines, ligand development, and study of localized active areas of the brain as a function of various stimuli. -Specialized scientific studies and technologies that would contribute to the foundation for key research areas such as: peripheral blockers; circulating drug interceptors; substitute medications and partial agonists for addiction; blocking drug effects by regulating uptake of neurotransmitters; curtailment of drug-induced adaptive behavior such as compulsive self-administration; pharmacological phenomena and neurochemical effects relating to sensitization and tolerance; specialized medicine delivery systems, cue induced craving; significance ofvarious rewards; and the study of the effects and degree of genetic contributions to drug use. -Innovative clinical methodology and treatment studies and protocols for prevention and dealing with overdoses, withdrawal, and medium to long term maintenance. -Social and epidemiology-related analysis to compile and analyze data from selected nation-wide locations, juvenile diversionary programs, and other research resources for transmission to research and policy agencies at all levels in the government, treatment providers, and researchers in the addiction field. -Systems, methods, modalities and protocols that will assist understanding and detecting the use of performance-enhancing drugs such as anabolic and androgenic steroids by athletes competing locally, nationally, and internationally. -Methods and studies to improve the detection and measurement of illicit or banned substances in body fluids, techniques for assessing and monitoring drug addiction or abuse severity, and techniques for treatment/client matching. SYNOPSIS (White Papers)/PROPOSALS: To save preparation costs and other resources, Offerors are strongly encouraged to submit an initial synopsis (commonly referred to as a "white paper") not to exceed 10 pages with technical description of the effort, a preliminary schedule, identification of risks, and a rough cost estimate. Offerors must submit seven (7) copies of all synopsis/white papers and must clearly reference this BAA number. The synopsis will be evaluated, and the Offeror notified as to possible interest by the Government. The Government reserves the right to request a proposal from any, all, part of, or none of the white papers. Upon favorable notification the Offeror will be invited to submit a full proposal within 45 days. Such notification will confirm that the offeror's white paper addresses areas of interest, will add relevance to mission requirements and the offeror has a reasonable chance for a competitive award based on subsequent evaluation of the offeror's full proposal. There willbe no debriefing of non-selected white papers. Offerors submitting full proposals should obtain a Proposer's Information Pamphlet (PIP) entitled "BAA 00-X-6004 Research and Development in Drug Demand Reduction and Support". This document provides further information on the submission and proposal formats. This pamphlet may be obtained from web site, e-commerce.spawar.navy.mil, under Business Opportunities for SPAWARSYSCEN, San Diego, referenced to this BAA number. If the Proposer does not have a means to access the web site, the pamphlet can be obtained by fax, electronic mail, or mail request to the administrative contact address given below. Proposals not meeting the format described in the pamphlet may not be reviewed. BAA MILESTONES: White papers may be submitted at any time prior to the closing date of 30 March 2001 and should be unclassified. White papers received in the first 90 calendar days after this BAA's publication date will be assessed as the first group; white papers received in the following four months will be assessed as the second group; white papers received after that will be assessed on the basis of funds availability. EVALUATION CRITERIA/PROCEDURE White papers and proposals will be selected through a formal procedure encompassing an academia/technical/scientific and counterdrug decision review process. All selected proposals may not be funded due to budgetary or program constraints. Offerors are advised that white papers and full proposals my be evaluated by personnel employed by a Federal Research & Development Center, each of whom will have signed both a non-disclosure agreement and an organizational conflict of interest statement. Both white papers and invited proposals will be evaluated with respect to the following criteria in descending order of importance: (1) Overall scientific and technical merit;-feasibility of proposed project; awareness of challenges;-awareness of past and on-going research and related applications worldwide;-potential for advancement of scientific understanding of the problem;-degree of creativity and innovation. (2) Potential contribution, relevance, and impact on the National Drug Control Policy's Goals and Objectives, as they relate to Demand Reduction. The ONDCP Goals and Objectives are posted on the ONDCP web site, www.whitehousedrugpolicy.gov; -understanding the importance of the problem;-significant understanding of the scientific basis and advance technology applications.-encouragement and promotion of opportunities for professional graduates to select careers related to research in drug substance abuse. (3) Capabilities and experience (including subcontractors)-qualifications and experience of the research/project team;-relevance of published peer-reviewed journal articles;-sound management plan and experience;-plans for a sound transition to meet ONDCP goals. (4) Cost and schedule realism (Proposals Only)-costs relative to perceived benefits;-project's plans and schedule; -appropriate budgets, levels of efforts with reasonable description of details;OFFEROR INFORMATION: Numerous awards may result from the BAA. The number of proposals funded will depend upon the quality and merit of the proposals received and available funding. There will be no formal Request for Proposals or other solicitation with regard to the BAA, nor does the issuance of the BAA obligate the Government to fund any subsequently invited proposals, nor pay any proposal preparation costs. All interested parties are invited to respond notwithstanding whether a synopsis was first submitted or a submission lead to a favorable invitation for a full proposal. All responsible parties' responses will be considered. Although no portion of this announcement is set aside for historically black colleges and universities (HBCU's) or minority institutions (MI's) participation, proposals are invited from all sources. The administrative address for this BAA is: Space and Naval Warfare Systems Center (SPAWARSYSCEN, San Diego), Attn: Ms Maureen Battern, Code D212, 53560 Hull Street, San Diego, CA 95215-5001. Any administrative questions may be addressed to Ms. Maureen Battern at (619) 553-4489, battern@spawar.navy.mil. Questions of a technical nature may be submitted, by email only, to Dr. Wadad Brooke Dubbelday, email dubbelda@spawar.navy.mil. The Government reserves the right to select for award, all, some, or none of the proposals received in response to this announcement. The Government may also only select specific tasks within a proposal for award. The Government further reserves the right to issue contracts, grants, cooperative agreements or other transactions This notice constitutes a BAA as contemplated in FAR 6.102(d)(2). NO HARD COPY VERSIONS OF THIS SOLICITATION WILL BE AVAILABLE. Posted 03/07/00 (W-SN431952). (0067)

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