National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

R -- PROFESSIONAL, ADMINISTRATIVE, AND MANAGEMENT SUPPORT SERVICES SOL RFQ-NCI-00081 DUE 032700 POC Cynthia Brown, Purchasing Agent, 301-402-4509, Gail Zois, Contracting Officer The National Institutes of Health (NIH), National Cancer Institute (NCI) plans to procure services for the ongoing NCI Prostrate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial from Dr. Anthony B. Miller, Senior Epidemiologist, Office of the Director, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon cedex 08, France. The PLCO which involves multiple study centers, is a large-scale, randomized study to determine whether certain screening tests will reduce the number of deaths from associated cancers. An experienced epidemiologist is required to provide scientific expertise for projects that support the PLCO over a one year base period of performance and four, one year option period, if exercised (approximately 275 hours each year). The projects to be supported include but are not limited to the following: 1) Health-related quality of life (HRQOL) and cost-effectiveness studies, 2) Death review in the PLCO trial, 3) Pathology review in the PLCO trial, and 4) Preparation of scientific papers for the PLCO trial and the International Prostrate Screening Trial Evaluation Group (IPSEG). The activities under these projects require thorough familiarity protocol design for efficient implementation and execution of protocols within the PLCO trial. The Contractor shall also review and prepare critiques of five ongoing PLCO studies. Based on the investigation, the Contractor shall: 1) identify gaps in the knowledge base and provide direction for the design and execution of projects; 2) organize and facilitate improvements for the studies; 3) review and provide recommendations on meeting minutes involving complex scientific matters; 4)preparation of scientific papers for the various trials and 5) provide guidance and scientific support to all phases of the above trial related to epidemiology, death reviews, pathology, quality assurance auditing at screening centers; protocol design and procedures. Dr. Miller was previously awarded a purchase order for this project, and his continued follow-up is necessary to maintain continuity within the trials. Specifically, he has been involved with the auditing of screening centers, and he has an extensive history in working with PLCO to draw upon in providing recommendations. His follow through from his recommendations for design through implementation and execution is essential to avoid disruptions to the studies. In addition, he is an expert in establishing clinical trials, particularly when they involve multiple centers. He has completed manuscripts analyzing the scientific value of international collaboration between European, Canadian, and US organizations, and he is an accepted expert throughout the world on clinical trials and international collaborations such as the PLCO. Dr. Miller is the only source known to the NCI researcher that can provide the required services and expertise noted above, especially with regard to trials design, auditing, and experience with international collaborations as noted above. This is not a solicitation for competitive quotations. However, if any interested party believes it can provide the above service, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. Capability statements must be received in the contracting office by 2:00 p.m. EST, on March 27, 2000. For further information please contact Cynthia Brown, Purchasing Agent,(301)-402-4509. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. Posted 03/09/00 (W-SN432689). (0069)

Loren Data Corp. http://www.ld.com (SYN# 0074 20000313\R-0015.SOL)