National Cancer Institute, Acquisition Management Branch, TBS, 6120 Executive Blvd, EPS/Rm 603 Bethesda, MD 20892-7220

B -- RESYNTHESIS OF COMPOUNDS FOR PRECLINICAL DEVELOPMENT SOL N02-CM-07004-54 DUE 052500 POC Kathleen E Giuliano, Contract Specialist, 301-435-3821 E-MAIL: Kathleen E Giuliano, guiliank@mail.nih.gov. The Developmental Therapeutics Program (DTP) of the National Cancer Institute (NCI), Division of Cancer Treatment and Diagnosis (DCTD) is soliciting organizations with expertise in organic synthesis to perform resynthesis of compounds needed for biological evaluations as potential anticancer agents. The Contractor shall synthesize target compounds as prioritized by NCI and deliver the synthesized compounds in amounts of 0.1 to 10.0 grams to the NCI repository. The synthesis assignments may include parallel synthesis or de-convolutions of small combinatorial libraries; and synthesis of selected analogs. This solicitation is anticipated to result in multiple awards to offerors capable of performing the types of work described in the statement of work. The Contractor shall prepare Material Safety Data Sheets for all single compounds and libraries which are delivered, and check the purities of compounds when requested. The contract type is a multiple award, work assignment contract for a period of three years with two one-year options. Offerors will be invited to submit proposals for 5500 direct labor hours per year. The following mandatory qualification criteria will apply: (1) the Contractor cannot be a commercial pharmaceutical, chemical or biotechnology firm since agents of a commercially confidential nature (discreet) may be evaluated; (2) as many of the compounds assigned for resynthesis may be of a hazardous nature, the Contractor shall have the necessary licenses required by Local, State and Federal Governments to handle, synthesize, store and ship such compounds and dispose of toxic waste. SIC for this acquisition is 8734. The solicitation is scheduled for electronic release o/a April 10, 2000. This acquisition has been designated as a 100% small business set-aside. The RFP may be accessed through the Research Contracts and Acquisition Branch homepage by using the following internet address: http://amb.nci.nih.gov It is the offeror's responsibility to monitor the above internet site for the release ofthis solicitation and any amendments. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS. No collect calls will be accepted. See Numbered Note 1. LINKURL: http//amb.nci.nih.gov/RFP.HTM LINKDESC: <A HREF="http//amb.nci.nih.gov/RFP.HTM">Research Contracts Branch Solicitation Website</A> EMAILADD: giuliank@mail.nih.gov EMAILDESC: <A HREF="mailto:giuliank@mail.nih.gov EMAILDESC: giuliank@mail.nih.gov">giuliank@mail.nih.gov</A> Posted 03/15/00 (W-SN434630). (0075)

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