NCI Frederick Cancer Research and Development Center (NCI-FCRDC), P.O. Box B, Frederick, Maryland 21702-1201

A -- BEAM LINE DEVELOPMENT SOL S00-142 DUE 042000 POC Point of Contact -- Thomas L. Danver (301) 846-5422, Contracting Officer -- Dennis J. Dougherty (301) 846-1087 WEB: Beam Line Development, http://www.nigms.nih.gov/news/announcements/beamline_sow.html. E-MAIL: Research and Construction Contracts, tdanver@mail.ncrifcrf.gov. The National Institute of General Medical Science (NIGMS) and the National Cancer Institute (NCI) of the National Institutes of Health (NIH) are partnering to establish a user facility for crystallograhic structure determination of biological macromolecules by X-ray diffraction at the Advanced Photon Source (APS) at the Argonne National Laboratory. This facility will occupy one full sector on the floor at the APS and consist of two or alternatively three experimental end stations for state-of-the-art X-ray macromolecular crystallography based on independently operating bending magnet and insertion device beam lines. The design of this facility will emphasize high-throughput employing the multiwavelength anomalous dispersion (MAD) method of diffraction data collection in all station positions. The elements of the design should deliver stable high resolution monochromatic X-rays rapidly tunable from 3.5 to 35 keV in a spot size on the order of 100 microns to a fixed position in the experimental station. Collimation of the X-ray beam should be maintained and the beam attributes of the radiation sources should not be compromised. We anticipate the publication of a solicitation for the design and/or construction of this facility within six (6) weeks of the appearance of this synopsis notice. Interested parties should fax a brief statement of capabilities to Thomas L. Danver, (301) 846-5414. It is anticipated that this will be the only announcement of the availability of the proposed solicitation. A draft statement of work for this project can be accessed at the following web-site: http://www.nigms.nih.gov/news/announcements/beamline_sow.html . Comments on any aspect of the draft SOW are welcome and should be directed to the contracting officer. If comments and expressed interests are sufficient, then a presolicitation conference may be scheduled and those parties expressing interest will be afforded an opportunity to attend. Posted 03/17/00 (W-SN435527). (0077)

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