National Institute on Drug Abuse, Contracts Management Branch, 6001 Executive Blvd., Room 3105, MSC 9543, Bethesda, MD 20892-9543

A -- NICOTINE BRAIN BANK SOL N01DA-0-9901 DUE 053000 POC Dale Weiss, Contracting Officer, Phone 301-443-6677, E-Mail dw79f@nih.gov The National Institute on Drug Abuse, Intramural Research Program (IRP) intends to negotiate with the University of Colorado, Denver Colorado, for a 2 year contract, with 3 one year options, to provide the IRP with the services of a nicotine brain bank. The contractor will be responsible for collecting and storing human brains of nicotine abusers. A detailed medical and nicotine history will be collected on all specimens stored. The brains will be collected in accordance with the Uniform Anatomical Gift Act. The University of Colorado is the only known brain bank that conducts the measurement of nicotinic receptors and their genes and other biological molecules, in human post mortem brain tissue. In addition it is the only brain bank that has a proven technique for the acquisition and preservation of human brain tissue, which retains the mRNA and protein integrity that is required for molecular biological research. Authority: 41 U.S.C. 253 c (1), as set forth in FAR 6.302-1. See numbered Notes 22 and 26. Posted 03/29/00 (W-SN439134). (0089)

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