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COMMERCE BUSINESS DAILY ISSUE OF MAY 4,2000 PSA#2593Director, USAMRAA, 820 Chandler St, Fort Detrick, MD 21702-5014 A -- NEUROTOXIN EXPOSURE TREATMENT RESEARCH PROGRAM SOL CBD-NRP-0502
POC Craig D. Lebo, Contracting Officer, 301-619-2036 U.S. Army Medical
Research and Materiel Command is soliciting research proposals for
studies on the pathophysiology and treatment of neurodegenerative
diseases, including Parkinson's disease, and including environmental
and stress exposure factors encountered in military operations which
may be neurotoxic or lead to neurodegenerative conditions. An improved
understanding of the pathophysiology of neurodegenerative diseases
will form the basis of potential preventive measures against the
effects of military threat agents and military operational hazards, and
also lead to treatment interventions for Parkinson's disease. We
solicit proposals on a broad range of basic and applied science,
including but not limited to these areas of interest: (1) influence of
environmental factors such as exposure to toxic substances, head
injury, shock, radiofrequency radiation and chronic stress in the
mediation of neural cell death, (2) development and validation of new
approaches to early detection of neurodegenerative disease, (3) new
therapeutic strategies for the treatment of neurodegenerative disease,
including neural cell transplantation, neuroprotection, and alteration
of cell biology through gene regulation and other novel methods.
Proposals will be selected for funding on the basis of scientific
quality and military relevance. Scientific quality is assessed by
independent peer review. Projects are typically 2-4 years in duration
and must be completed by 30 September 2006. Program projects will not
be considered. Approximately $9M is available for the lifespan of these
projects. A special category of "concept exploration" proposals (CEP)
will also be considered this year. CEPs allow investigators to conduct
pilot studies and develop preliminary data for novel hypotheses that
fall within the specific topic areas, with the intent that full
proposals submitted to future solicitations may further expand on CEP
successes; total direct costs for these studies should not exceed
$100K; approximately 10 concept exploration proposals are expected to
be funded; previously untested concepts and investigators new to this
field of research will receive priority. Proposals must be submitted
according to general instructions contained in the Broad Agency
Announcement 99-1 (see http://www-usamraa.army.mil). Letters of intent
containing a proposed title, brief description of project scope
(<150 words), and investigator and institution identification, are
encouraged and should be sent by 16 August 2000; these are for planning
purposes and investigators will NOT be sent any response to letters of
intent. Full proposals are due by 4:00 p.m. EST, Wednesday, 20
September 2000. Send letters of intent and proposals to: Commander,
U.S. Army Medical Research and Materiel Command, ATTN: MCMR-AAA
(Neurotox), 820 Chandler Street, Fort Detrick, MD 21702-5014. Posted
05/02/00 (W-SN450295). (0123) Loren Data Corp. http://www.ld.com (SYN# 0010 20000504\A-0010.SOL)
A - Research and Development Index Page
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