National Cancer Institute, Research Contracts Branch, Office of the Chief, Executive Plaza South, MSC 7222, 6120 Executive Blvd., Room 608, Bethesda, MD 20892-7222

B -- SUPPORT SERVICES FOR THE CALIFORNIA CEREBRAL PALSY STUDY SOL N02-NS-09001-09 POC Mary E. landi O'Leary; Contracting Officer; 301/435-3807 E-MAIL: Mary E. Landi O'Leary, ml186r@nih.gov. The National Cancer Institute (NCI), on behalf of the National Institute of Neurological Disorders and Stroke (NINDS), Neuroepidemiology Branch, plans to procure the services of the March of Dimes in California, 3031 "F" St. #100, Sacramento, CA 95816. The support services are needed for the study of the California Cerebral Palsy Project. Background: The Neuroepidemiology Branch has been investigating the etiology and mechanisms of disease in cerebral palsy, mental retardation and autism, in cooperation with the March of Dimes/California Birth Defects Monitoring Program, Cerebral Palsy Project. The objective of the studies is to identify and conduct case-control studies in children with moderate or severe congenital palsy, or in those with mental retardation or autism. Requirement: The Contractor shall provide the necessary facilities, personnel, supplies and supervision required to provide the NINDS with support services for the California Cerebral Palsy Project. The project has been ongoing and inorder to continue the analyses of data, the contractor shall be responsible for: 1. Prepare written reports on the newborn screening blood spots pulled and submitted to laboratory for analysis. 2. Linking the California Cerebral Palsy Project data bases with Newborn Screening data base to obtain thyroid screening data on children with cerebral palsy (CP), mental retardation, autism and control children, including file management and documentation. 3. Perform record linkage of children with these conditions with CA Genetic Disease Branch data on newborn screening and data on prenatal diagnosis. 4. Conducting basic analyses of association between newborn screening thyroid values and risk of CP among very low birthweight (VLBW) babies 5. Preparing written reports on final results to be used as a basis for published articles including creating, managing, and documenting analytic files of data on VLBW babies with CP and control babies. 6. Examine the role of maternal infection and risk of CP. Conducting basic analyses of the association between maternal infection and risk of CP in VLWB babies. 7. Providing a research assistant to work with the Project manager/Epidemiologist in preparing written reports on the results which will serve as a basis for published articles. The Neuroepidemiology Branch plans to award a cost reimbursement, level -of-effort contract for a base year with four one-year options. Since only the March of Dimes has rights to the data for these ongoing studies, the March of Dimes is the only known source that can meet the above requirements. Authority for this action is 41 USC 253 (c.)(1), as set forth in FAR6.302-1. Numbered Note 22 applies. Posted 05/02/00 (W-SN450434). (0123)

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