Centers For Disease Control And Prevention (CDC), Procurement & Grants Office, 2920 Brandywine Road, Atlanta, Georgia 30341-4146

A -- ANTHRAX VACCINE RESEARCH PROGRAM SOL 2000-N-00065 DUE 071300 POC Lorenzo J. Falgiano, Section III, MS K-70, 770-488-2629 The Centers for Disease Control and Prevention contemplates multiple awards for contracts to conduct one or more studies of the anthrax vaccine; the CDC is has been tasked by congress to also study the safety and efficacy of vaccines used against biological agents; this multi-site, multi-study anthrax vaccine research project will involve humans and/or animal subjects. The data obtained from these studies will possibly support changes in the route of vaccine administration and possibly reduce the number of doses in the currently recommended anthrax vaccination series. The studies would specifically address (1) the risk factors for adverse events between men and women; (2) determining immunological correlates of protection and documenting vaccine efficacy, and (3) optimizing the vaccination schedule and administration to assure efficacy while minimizing the number of doses required and the occurrence of adverse events. Additional information surrounding human, animal and immunologic research is needed to specifically address items (2) and (3) above and these studies are expected to serve as a scientific basis for decisions regarding changes in the route of vaccination administration and provide a scientific platform for development of new vaccines for anthrax. The period of performance will vary between the studies from 40 months to sixty months; the studies will be incrementally funded based upon the government's availability of funds for each fiscal year. The schedule issue date is approximately May 24, 2000. No telephone requests will be accepted; only written requests for this solicitation will be honored. Requests should site RFP Number 2000-N-00065. All responsible sources that meet the above requirements may submit a proposal which shall be considered by the Agency. Posted 05/11/00 (W-SN454052). (0132)

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