National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

B -- SERUM ORGANOCHLORINE LEVELS AND RISK OF SELECTED CANCERS SOL NCI-RFQ-00124-NV DUE 060200 POC Debbie Moore, Purchasing Agent 301-402-4509, Todd Cole, Contracting Officer 301-402-4509 The National Cancer Institute intends on procuring services from the Cancer Registry of Norway, Montebello N-0310, Oslo, Norway, to provide necessary resources and data required in an NCI study of environmental chemicals and cancer. NCI is conducting a study to evaluate the risk of cancer from exposure to organohalide chemicals. These chemicals accumulate in the adipose tissue and persist for many years. Data from the JANUS Serum Bank shall be used in this study to address the issue. The JANUS Serum Bank in Norway is composed of serum samples on over 250,000 Norwegians, which were collected in the early 1970s. The project will use data from this source to evaluate the potential relationship between levels of these chemicals in blood collected 25 years ago and the development of non-Hodgkin's lymphoma, leukemia, multiple myeloma, melanoma, and cancers of the brain, prostate, testes, ovary and endometrium. The Cancer Registry of Norway can perform the services required for this study for the following reasons: 1) this Registry has a significant number of serum samples (more than 200,000 are required) collected from a homogenous population over several years (greater than 20 years); 2) it can determine who among these serum bank subjects have developed cancer; and 3) it can provide additional demographic information each subject in the JANUS system. The serum samples, combined with the significant sample size, regular medical follow-up and demographic data, provide a great opportunity for study the noted relationships. The JANUS Serum Bank is proprietary to the Cancer Registry of Norway. The Cancer Registry of Norway is the only source known by the NCI researcher that has the necessary samples, follow-up, and other features noted herein to meet the study parameters. This is not a request for quotations. However, if any interested party believes it can meet these requirements, it may submit a capability statement to the contracting office by June 2, 2000 at 1:00 PM EDT (local Washington, D.C. time). Information furnished must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform the requirement. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Please contact Debbie Moore at (301)402-4509 for additional information. No Collect calls will be accepted. Posted 05/17/00 (W-SN455868). (0138)

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