Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office, 2920 Brandywine Road, Room 3000, Atlanta, GA, 30341-4146

A -- SENTINEL COUNTIES STUDY OF ACUTE VIRAL HEPATITIS SOL 2000-N-00099 DUE 082900 POC Elmira Benson, Contract Specialist, Phone (770)488-2628, Fax (770)488-2670, Email EBenson@CDC.GOV WEB: Visit this URL for the latest information about this, http://www.eps.gov/cgi-bin/WebObjects/EPS?ACode=P&ProjID=2000-N-00099&; LocID=2965. E-MAIL: Elmira Benson, EBenson@CDC.GOV. 17.The CDC contemplates making multiple awards for contracts to conduct one or more studies to monitor trends in the incidence and epidemiology of hepatitis A, B, C and other non-A, non-B hepatitis, determine missed opportunities for prevention, such as vaccination, and develop and maintain a database of persons identified with chronic hepatitis B virus infection and all persons who are positive for antibody to hepatitis C viruses. To be eligible for an award, each offeror must propose sites that meet the following ABSOLUTE CRITERIA: 1) One which is geographically well defined to insure that persons with viral hepatitis will seek primary medical care within that area; the census of the catchment area should be no less 450,000 and no more than 950,000. 2)A well-established system of surveillance for acute disease and provide documentation for the capacity to conduct surveillance using routine laboratory reports for acute hepatitis A; acute and chronic B viruses (HBV) infection; and acute and chronic hepatitis C viruses (HCV) infection. 3) An average of at least 50 to 75 cases of acute viral hepatitis per year during 1996 to 1999. 4) Evidence of serologic testing for hepatitis B surface antigen (HBsAg) and IgM antibody to hepatitis A viruses (anti-HAV) on at least 80% of all reported cases of acute viral hepatitis from 1996 to 1999. 5) Clinical, demographic, and risk factor data on at least 50% of all reported cases of acute viral hepatitis by type from 1996 to 1999. Such data must conform with the information requested on the CDC Hepatitis Investigation Form CDC 50.40-1-91. 6) Access to a population of clinically and serologically well-defined patients with chronic hepatitis C and other NANB hepatitis whose sources for infection are representative of the spectrum of community acquired disease; and have serologic, a virologic and biochemical follow-up for at least 13 years from the onset of the acute disease. The contemplated period of performance is 60 months from the contract award date. The studies will be incrementally funded based upon the Government's availability of funds for each fiscal year. The schedule issue date is approximately June 29, 2000. NO TELEPHONE REQUESTS WILL BE ACCEPTED; ONLY WRITTEN REQUESTS FOR THIS SOLICITATION WILL BE HONORED. Written requests should cite RFP No. 2000-N-00099. Facsimile requests may be sent to (770) 488-2670. Electronic requests may be sent to ecb2@CDC.gov. All responsible sources that meet the above requirements may submit a proposal which shall be considered by the Agency. Posted 05/31/00 (D-SN460178). (0152)

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