National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- 500MHZ HIGH PERFORMANCE DIGITAL NMR SPECTROMETER SOL NCI-RFQ-00133-NV DUE 062100 POC Debbie Moore, Purchasing Agent, 301-402-4509, Todd Cole, Contracting Officer (301) 402-4509 The National Cancer Institute (NCI), Laboratory of Biochemistry intends to procure on a sole source basis in accordance with FAR 6.302-1, for a Nuclear Magnetic Resonance (NMR) Spectrometer for studies of protein structure, folding, dynamics, and their relationship to protein functions with Bruker Instruments, Inc., Manning Park, 44 Manning Road, Billerica, MA 01821. The Laboratory of Biochemistry plans to extend its research area that will include studies of protein structure, folding, dynamics, and their relationship to protein functions. NIH at Bethesda is equipped with ten (10) high field nuclear magnetic resonance (NMR) spectrometers that are used to study proteins. An additional NMR instrument is required that will provide the most advanced high performance Nuclear Magnetic Resonance (NMR) equipment that is available on the market with the minimum field strength that can be used to study proteins. The NMR spectrometer shall meet or exceed the following minimum performance specifications: (1) the console and the actively shielded magnet shall be capable of operating at or above 500 MHz frequency; (2) provide shielding for all electronics; (3) include a communication control unit having at least a 100 megahertz processor; (4) allow for performing experiments without changing cables; (5) include a digital router software controlled; (6) allow for observation of low gamma nuclei as far down as 6 megahertz; (7) provide real time digital filtering of NMR data; (8) each frequency source (frequency control unit) shall have a minimum wave form memory of 64 kiloword to allow for better pulse definition; (9) user shall be able to adjust phase to within 0.05 degrees; and (10) software control and pulse sequence programming must be fully compatible with existing Bruker instruments. This compatibility is a major component. There are approximately 50 sequences that were developed by various NIH Investigators using the existing Bruker NMR machines. All pulse sequences developed at this campus and in other areas areshared with other colleagues that utilize the same software. Bruker Instrument, Inc., is the only source than can fully achieve the compatibility requirement in terms of pulse sequences (software) and probes (hardware). This notice of intent is not a request for competitive proposal. However, if any interested party believes it can meet the above requirement, they may submit a statement of capabilities, must clearly demonstrate that the existing sequences can be converted, and that the instrument can fully meet all the above specifications. If demonstration is determined to be acceptable, the source must concur to converting all sequences for the instrument at no additional cost to the Government, and prior to award of this acquisition. An original and one copy of information furnished shall be in writing and must contain sufficient detail, to allow NCI to determine if the party can meet the requirement. Capability statements must be received in the Contracts Office by 1PM EDT on June 21, 2000. If you have any questions, please contact Debbie Moore, Purchasing Agent (301) 402-4509. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Posted 06/02/00 (W-SN460743). (0154)

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