A -- IMMUNE TOLERANCE NETWORK The National Institute of Allergy and Infectious Diseases intends to negotiate a contract on a sole source basis with the University of California -- San Francisco (UCSF) to conduct the work of the Immune Tolerance Network. The network will: (1) develop a long-term scientific agenda for clinical trials and mechanistic studies; (2) design and conduct clinical trials at all phases to determine the safety, toxicity and efficacy of tolerogenic treatment strategies for multiple immune system diseases; (3) design and conduct research to delineate the underlying mechanisms of immune tolerance as an integral part of the clinical trials undertaken by the Collaborative Network, as well as clinical trials sponsored by other Federal and private sector organizations and companies; and (4) develop and validate biomarkers and assays of immune tolerance in humans. The proposed award represents a continuation of work originally awarded to The University of Chicago (under contract NO1-AI-95380) in 1999. The Network Center Office intends to relocate to UCSF. Authority: 41U.S.C. 253(c)(1), as set forth in FAR 6.302-1. Only one responsible source and no other source will satisfy agency requirements. See Numbered Posted 06/02/00 (W-SN460801).

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